Publication

Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults

Opie, G. M., Post, A. K., Ridding, M. C., Ziemann, U. & Semmler, J. G., May-2017, In : Clinical Neurophysiology. 128, 5, p. 763-769 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Opie, G. M., Post, A. K., Ridding, M. C., Ziemann, U., & Semmler, J. G. (2017). Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults. Clinical Neurophysiology, 128(5), 763-769. https://doi.org/10.1016/j.clinph.2017.02.011

Author

Opie, George M. ; Post, Aylin K. ; Ridding, Michael C. ; Ziemann, Ulf ; Semmler, John G. / Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults. In: Clinical Neurophysiology. 2017 ; Vol. 128, No. 5. pp. 763-769.

Harvard

Opie, GM, Post, AK, Ridding, MC, Ziemann, U & Semmler, JG 2017, 'Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults', Clinical Neurophysiology, vol. 128, no. 5, pp. 763-769. https://doi.org/10.1016/j.clinph.2017.02.011

Standard

Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults. / Opie, George M.; Post, Aylin K.; Ridding, Michael C.; Ziemann, Ulf; Semmler, John G.

In: Clinical Neurophysiology, Vol. 128, No. 5, 05.2017, p. 763-769.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Opie GM, Post AK, Ridding MC, Ziemann U, Semmler JG. Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults. Clinical Neurophysiology. 2017 May;128(5):763-769. https://doi.org/10.1016/j.clinph.2017.02.011


BibTeX

@article{357eddcd08eb43f5aac970a87d9b0642,
title = "Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults",
abstract = "Objective: To examine the effect of priming paired associative stimulation (PAS) on the modulation of motor cortex (M1) plasticity in young and old adults.Methods: Fifteen young (20-27 yrs) and 15 old (61-79 yrs) subjects participated in 3 experimental sessions, with each session involving two consecutive PAS protocols separated by 10 mins. The first (priming) protocol was either PAS(LTP) (ISI = N20 latency + 2 ms), PASLTD (ISI = N20 latency - 10 ms), or PAS(Control) (ISI = 100 ms), whereas the second (test) protocol was always PASLTP. Changes in M1 excitability were assessed from motor evoked potentials (MEPs) in a hand muscle.Results: In young subjects, MEPs were larger after PAS(LTP) + PAS(LTP) than PAS(LTD) + PAS(LTP) (P <0.0001) and PAS(Control) + PAS(LTP) (P = 0.0008), whereas the response to PAS(Control) + PAS(LTP) was not different to PAS(LTD) + PAS(LTP) (P = 0.3). In old subjects, MEPs were smaller after PAS(LTP) + PAS(LTP) compared with PAS(Control) + PAS(LTP) (P = 0.02), whereas PAS(LTD) + PAS(LTP) was similar to PAS(Control) + PAS(LTP) (P = 0.08). Age-related comparisons within each priming condition showed that the response to PAS(LTP) + PAS(LTP) was significantly greater in young subjects (P = 0.03).Conclusion: Data show that priming with PASLTP was effective in young but not old subjects.Significance: These findings suggest a limited utility of priming PAS for augmenting plasticity induction in old adults. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.",
keywords = "Ageing, Primary motor cortex, Transcranial magnetic stimulation, Paired-associative stimulation, Neuroplasticity, Metaplasticity, LONG-TERM POTENTIATION, INTERINDIVIDUAL VARIABILITY, DIFFERENTIAL MODULATION, DEPENDENT PLASTICITY, CORTEX EXCITABILITY, NERVE-CONDUCTION, AGE-DEPENDENCE, METAPLASTICITY, INDUCTION, PROTOCOLS",
author = "Opie, {George M.} and Post, {Aylin K.} and Ridding, {Michael C.} and Ulf Ziemann and Semmler, {John G.}",
year = "2017",
month = may,
doi = "10.1016/j.clinph.2017.02.011",
language = "English",
volume = "128",
pages = "763--769",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "ELSEVIER IRELAND LTD",
number = "5",

}

RIS

TY - JOUR

T1 - Modulating motor cortical neuroplasticity with priming paired associative stimulation in young and old adults

AU - Opie, George M.

AU - Post, Aylin K.

AU - Ridding, Michael C.

AU - Ziemann, Ulf

AU - Semmler, John G.

PY - 2017/5

Y1 - 2017/5

N2 - Objective: To examine the effect of priming paired associative stimulation (PAS) on the modulation of motor cortex (M1) plasticity in young and old adults.Methods: Fifteen young (20-27 yrs) and 15 old (61-79 yrs) subjects participated in 3 experimental sessions, with each session involving two consecutive PAS protocols separated by 10 mins. The first (priming) protocol was either PAS(LTP) (ISI = N20 latency + 2 ms), PASLTD (ISI = N20 latency - 10 ms), or PAS(Control) (ISI = 100 ms), whereas the second (test) protocol was always PASLTP. Changes in M1 excitability were assessed from motor evoked potentials (MEPs) in a hand muscle.Results: In young subjects, MEPs were larger after PAS(LTP) + PAS(LTP) than PAS(LTD) + PAS(LTP) (P <0.0001) and PAS(Control) + PAS(LTP) (P = 0.0008), whereas the response to PAS(Control) + PAS(LTP) was not different to PAS(LTD) + PAS(LTP) (P = 0.3). In old subjects, MEPs were smaller after PAS(LTP) + PAS(LTP) compared with PAS(Control) + PAS(LTP) (P = 0.02), whereas PAS(LTD) + PAS(LTP) was similar to PAS(Control) + PAS(LTP) (P = 0.08). Age-related comparisons within each priming condition showed that the response to PAS(LTP) + PAS(LTP) was significantly greater in young subjects (P = 0.03).Conclusion: Data show that priming with PASLTP was effective in young but not old subjects.Significance: These findings suggest a limited utility of priming PAS for augmenting plasticity induction in old adults. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

AB - Objective: To examine the effect of priming paired associative stimulation (PAS) on the modulation of motor cortex (M1) plasticity in young and old adults.Methods: Fifteen young (20-27 yrs) and 15 old (61-79 yrs) subjects participated in 3 experimental sessions, with each session involving two consecutive PAS protocols separated by 10 mins. The first (priming) protocol was either PAS(LTP) (ISI = N20 latency + 2 ms), PASLTD (ISI = N20 latency - 10 ms), or PAS(Control) (ISI = 100 ms), whereas the second (test) protocol was always PASLTP. Changes in M1 excitability were assessed from motor evoked potentials (MEPs) in a hand muscle.Results: In young subjects, MEPs were larger after PAS(LTP) + PAS(LTP) than PAS(LTD) + PAS(LTP) (P <0.0001) and PAS(Control) + PAS(LTP) (P = 0.0008), whereas the response to PAS(Control) + PAS(LTP) was not different to PAS(LTD) + PAS(LTP) (P = 0.3). In old subjects, MEPs were smaller after PAS(LTP) + PAS(LTP) compared with PAS(Control) + PAS(LTP) (P = 0.02), whereas PAS(LTD) + PAS(LTP) was similar to PAS(Control) + PAS(LTP) (P = 0.08). Age-related comparisons within each priming condition showed that the response to PAS(LTP) + PAS(LTP) was significantly greater in young subjects (P = 0.03).Conclusion: Data show that priming with PASLTP was effective in young but not old subjects.Significance: These findings suggest a limited utility of priming PAS for augmenting plasticity induction in old adults. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

KW - Ageing

KW - Primary motor cortex

KW - Transcranial magnetic stimulation

KW - Paired-associative stimulation

KW - Neuroplasticity

KW - Metaplasticity

KW - LONG-TERM POTENTIATION

KW - INTERINDIVIDUAL VARIABILITY

KW - DIFFERENTIAL MODULATION

KW - DEPENDENT PLASTICITY

KW - CORTEX EXCITABILITY

KW - NERVE-CONDUCTION

KW - AGE-DEPENDENCE

KW - METAPLASTICITY

KW - INDUCTION

KW - PROTOCOLS

U2 - 10.1016/j.clinph.2017.02.011

DO - 10.1016/j.clinph.2017.02.011

M3 - Article

VL - 128

SP - 763

EP - 769

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 5

ER -

ID: 47192609