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Modelling autistic features in mice using quantitative genetic approaches

Molenhuis, R. T., Bruining, H. & Kas, M. J., May-2017, Translational Anatomy and Cell Biology of Autism Spectrum Disorder. Schmeisser, M. J. & Boeckers, T. M. (eds.). Springer International Publishing AG, p. 65-84 20 p. (Advances in Anatomy Embryology and Cell Biology; vol. 224).

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  • Modelling Autistic Features in Mice Using Quantitative Genetic Approaches

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DOI

Animal studies provide a unique opportunity to study the consequences of genetic variants at the behavioural level. Human studies have identified hundreds of risk genes for autism spectrum disorder (ASD) that can lead to understanding on how genetic variation contributes to individual differences in social interaction and stereotyped behaviour in people with ASD. To develop rational therapeutic interventions, systematic animal model studies are needed to understand the relationships between genetic variation, pathogenic processes and the expression of autistic behaviours. Genetic and non-genetic animal model strategies are here reviewed in their propensity to study the underpinnings of behavioural trait variation. We conclude that an integration of reverse and forward genetic approaches may be essential to unravel the neurobiological mechanisms underlying ASD.
Original languageEnglish
Title of host publicationTranslational Anatomy and Cell Biology of Autism Spectrum Disorder
EditorsMichael J. Schmeisser, Tobias M. Boeckers
PublisherSpringer International Publishing AG
Pages65-84
Number of pages20
ISBN (Electronic)978-3-319-52498-6
ISBN (Print)978-3-319-52496-2
Publication statusPublished - May-2017

Publication series

NameAdvances in Anatomy Embryology and Cell Biology
PublisherSPRINGER INTERNATIONAL PUBLISHING AG
Volume224
ISSN (Print)0301-5556

    Keywords

  • TUBEROUS SCLEROSIS GENE, FRAGILE-X-SYNDROME, SPECTRUM DISORDERS, REPETITIVE BEHAVIOR, MOUSE MODEL, INBRED STRAINS, NEURODEVELOPMENTAL DISORDERS, COMPREHENSIVE METAANALYSIS, COGNITIVE FLEXIBILITY, SOCIAL APPROACH

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