Mobilization of hematopoietic stem and progenitor cells in miceRobinson, S. N. & van Os, R. P., 2008, Methods in Molecular Biology: Hematopoietic Stem Cell Protocols. Bunting, K. (ed.). III ed. Humana Press, Vol. 430. p. 31-53 23 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic
Animal models have added significantly to our understanding of the mechanism(s) of hematopoietic stem and progenitor cell (HSPC) mobilization. Such models suggest that changes in the interaction between the HSPC and the hematopoietic microenvironmental 'niche' (cellular and extracellular components) are critical to the process. The increasing availability of recombinant proteins (growth factors, cytokines, chemokines), antibodies, drugs (agonists and antagonists), and mutant and genetically modified animal models [gene knock-in (KI) and knock-out (KO)] continue to add to the tools available to better understand and manipulate mobilization processes.
|Title of host publication||Methods in Molecular Biology|
|Subtitle of host publication||Hematopoietic Stem Cell Protocols|
|Number of pages||23|
|Publication status||Published - 2008|
- Animals, Hematopoietic Stem Cells, Mice, Mice, Transgenic