Mobilization of hematopoietic stem and progenitor cells in mice

Robinson, S. N. & van Os, R. P., 2008, Methods in Molecular Biology: Hematopoietic Stem Cell Protocols. Bunting, K. (ed.). III ed. Humana Press, Vol. 430. p. 31-53 23 p.

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  • Hematopoietic Protocols - Chap3 -Robinson and Van Os

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Animal models have added significantly to our understanding of the mechanism(s) of hematopoietic stem and progenitor cell (HSPC) mobilization. Such models suggest that changes in the interaction between the HSPC and the hematopoietic microenvironmental 'niche' (cellular and extracellular components) are critical to the process. The increasing availability of recombinant proteins (growth factors, cytokines, chemokines), antibodies, drugs (agonists and antagonists), and mutant and genetically modified animal models [gene knock-in (KI) and knock-out (KO)] continue to add to the tools available to better understand and manipulate mobilization processes.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Subtitle of host publicationHematopoietic Stem Cell Protocols
EditorsKevin Bunting
PublisherHumana Press
Number of pages23
ISBN (Print)1064-3745
Publication statusPublished - 2008


  • Animals, Hematopoietic Stem Cells, Mice, Mice, Transgenic

ID: 13963418