Publication

Mms1 is an assistant for regulating G-quadruplex DNA structures

Schwindt, E. & Paeschke, K., Jun-2018, In : Current Genetics. 64, 3, p. 535-540 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The preservation of genome stability is fundamental for every cell. Genomic integrity is constantly challenged. Among those challenges are also non-canonical nucleic acid structures. In recent years, scientists became aware of the impact of G-quadruplex (G4) structures on genome stability. It has been shown that folded G4-DNA structures cause changes in the cell, such as transcriptional up/down-regulation, replication stalling, or enhanced genome instability. Multiple helicases have been identified to regulate G4 structures and by this preserve genome stability. Interestingly, although these helicases are mostly ubiquitous expressed, they show specificity for G4 regulation in certain cellular processes (e.g., DNA replication). To this date, it is not clear how this process and target specificity of helicases are achieved. Recently, Mms1, an ubiquitin ligase complex protein, was identified as a novel G4-DNA-binding protein that supports genome stability by aiding Pif1 helicase binding to these regions. In this perspective review, we discuss the question if G4-DNA interacting proteins are fundamental for helicase function and specificity at G4-DNA structures.

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalCurrent Genetics
Volume64
Issue number3
Publication statusPublished - Jun-2018

    Keywords

  • DNA secondary structures, Pif1 helicase, Genome stability, S. cerevisiae, SUPPRESS GENOME INSTABILITY, SACCHAROMYCES-CEREVISIAE, BUDDING YEAST, PROMOTES REPLICATION, BINDING-PROTEINS, DAMAGED DNA, HUMAN-CELLS, IN-VIVO, HELICASE, MOTIFS

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