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Minimally invasive coronary artery bypass grafting versus percutaneous transluminal coronary angioplasty with stenting in isolated high-grade stenosis of the proximal left anterior descending coronary artery: Six months' angiographic and clinical follow-up of a prospective randomized study

Drenth, DJ., Winter, JB., Veeger, NJGM., Monnink, SHJ., van Boven, AJ., Grandjean, JG., Mariani, MA. & Boonstra, PW., Jul-2002, In : JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY. 124, 1, p. 130-135 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Objective: We sought to compare minimally invasive coronary artery bypass grafting (surgical intervention) with percutaneous transluminal coronary angioplasty with primary stenting (stenting) in patients having an isolated high-grade stenosis (American College of Cardiology/American Heart Association classification type B2 or C) of the proximal left anterior descending coronary artery. At 6 months, both procedures were compared on the basis of quantitative angiography and clinical outcome.

Methods: Both treatments were compared in a single-center, prospective, randomized study. The primary end point of this study was quantitative angiographic outcome at 6 months. The secondary end point was 6-month clinical outcome. Statistical analysis was performed in accordance with the intention-to-treat principle.

Results: From March 1997 to September 1999, patients with angina pectoris caused by an isolated high-grade stenosis of the proximal left anterior descending, coronary artery were randomly assigned to surgical intervention (n = 51) or stenting (n = 51). At 6 months, quantitative coronary angiography showed an anastomotic stenosis rate of 4% after surgical Intervention and a restenosis rate of 29% after stenting (P

Conclusions: After 6 months, surgical intervention had a significantly better angiographic outcome than stenting in patients with an isolated high-grade stenosis of the proximal left anterior descending coronary artery. Clinical outcome did not significantly between treatments.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalJOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Volume124
Issue number1
Publication statusPublished - Jul-2002

    Keywords

  • INTERNAL-MAMMARY-ARTERY, CARDIOPULMONARY BYPASS, CARDIAC EVENTS, PLACEMENT, SURVIVAL, SURGERY

ID: 4028752