Publication

Milling of organic solids in a jet mill. Part 2: Checking the validity of the predicted rate of breakage function

de Vegt, O., Vromans, H., Faassen, F. & Maarschalk, KV., Jan-2006, In : Particle & Particle Systems Characterization. 22, 4, p. 261-267 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The particle size distribution of fine chemicals in the solid state, like active pharmaceutical ingredients, is often a critical parameter. To achieve the desired particle size distribution, milling of such materials is usually the method of choice. Since these chemicals are often scarcely available, experimental optimization of milling is not possible. Therefore, a model to predict the milling conditions has been developed. The model estimates the rate of breakage function, and needs mechanical properties like hardness and yield strength as input to calculate the rate of breakage function. This paper attempts to check the validity of the model by a series of experiments. A comparison of the experimental results with the outcomes of the model using five different model compounds has been performed. It appears that the rate of breakage function can be estimated by:

S-I 5.85 (+/- 1.78) 10(8) E-kin E-fract root P-V/rho/V H root x(i) K-1c .

The model is able to rank the compounds by degree of fracture as an effect of milling. It was also possible to perform a quantitative prediction of the impact of milling pressure on the milling behavior. Finally, it appeared that the prediction of the large particles in the distribution was significantly better than small ones. Because the oversized material is usually the most critical parameter, the conclusion is that the model has acceptable practical applicability.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalParticle & Particle Systems Characterization
Volume22
Issue number4
Publication statusPublished - Jan-2006

    Keywords

  • material properties, milling, model, particle size distribution, prediction, rate of breakage function

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