Publication

Microspheres with ultrahigh holmium content for radioablation of malignancies

Bult, W., Seevinck, P. R., Krijger, G. C., Visser, T., Kroon-Batenburg, L. M. J., Bakker, C. J. G., Hennink, W. E., van het Schip, A. D. & Nijsen, J. F. W., Jun-2009, In : Pharmaceutical Research. 26, 6, p. 1371-1378 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Bult, W., Seevinck, P. R., Krijger, G. C., Visser, T., Kroon-Batenburg, L. M. J., Bakker, C. J. G., ... Nijsen, J. F. W. (2009). Microspheres with ultrahigh holmium content for radioablation of malignancies. Pharmaceutical Research, 26(6), 1371-1378. https://doi.org/10.1007/s11095-009-9848-8

Author

Bult, W ; Seevinck, P R ; Krijger, G C ; Visser, T ; Kroon-Batenburg, L M J ; Bakker, C J G ; Hennink, W E ; van het Schip, A D ; Nijsen, J F W. / Microspheres with ultrahigh holmium content for radioablation of malignancies. In: Pharmaceutical Research. 2009 ; Vol. 26, No. 6. pp. 1371-1378.

Harvard

Bult, W, Seevinck, PR, Krijger, GC, Visser, T, Kroon-Batenburg, LMJ, Bakker, CJG, Hennink, WE, van het Schip, AD & Nijsen, JFW 2009, 'Microspheres with ultrahigh holmium content for radioablation of malignancies', Pharmaceutical Research, vol. 26, no. 6, pp. 1371-1378. https://doi.org/10.1007/s11095-009-9848-8

Standard

Microspheres with ultrahigh holmium content for radioablation of malignancies. / Bult, W; Seevinck, P R; Krijger, G C; Visser, T; Kroon-Batenburg, L M J; Bakker, C J G; Hennink, W E; van het Schip, A D; Nijsen, J F W.

In: Pharmaceutical Research, Vol. 26, No. 6, 06.2009, p. 1371-1378.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Bult W, Seevinck PR, Krijger GC, Visser T, Kroon-Batenburg LMJ, Bakker CJG et al. Microspheres with ultrahigh holmium content for radioablation of malignancies. Pharmaceutical Research. 2009 Jun;26(6):1371-1378. https://doi.org/10.1007/s11095-009-9848-8


BibTeX

@article{d21572dcb98b40ba94f2775c0815e2a1,
title = "Microspheres with ultrahigh holmium content for radioablation of malignancies",
abstract = "PURPOSE: The aim of this study was to develop microspheres with an ultra high holmium content which can be neutron activated for radioablation of malignancies. These microspheres are proposed to be delivered selectively through either intratumoral injections into solid tumors or administered via an intravascularly placed catheter.METHODS: Microspheres were prepared by solvent evaporation, using holmium acetylacetonate (HoAcAc) crystals as the sole ingredient. Microspheres were characterized using light and scanning electron microscopy, coulter counter, titrimetry, infrared and Raman spectroscopy, differential scanning calorimetry, X-ray powder diffraction, magnetic resonance imaging (MRI), and X-ray computed tomography (CT).RESULTS: Microspheres, thus prepared displayed a smooth surface. The holmium content of the HoAcAc microspheres (44{\%} (w/w)) was higher than the holmium content of the starting material, HoAcAc crystals (33{\%} (w/w)). This was attributed to the loss of acetylacetonate from the HoAcAc complex, during rearrangement of acetylacetonate around the holmium ion. The increase of the holmium content allows for the detection of (sub)microgram amounts of microspheres using MRI and CT.CONCLUSIONS: HoAcAc microspheres with an ultra-high holmium content were prepared. These microspheres are suitable for radioablation of tumors by intratumoral injections or treatment of liver tumors through transcatheter administration.",
keywords = "Calorimetry, Differential Scanning, Holmium, Humans, Hydroxybutyrates, Liver Neoplasms, Magnetic Resonance Imaging, Microspheres, Particle Size, Pentanones, Spectrum Analysis, Raman, Surface Properties, Tomography, X-Ray Computed, X-Ray Diffraction",
author = "W Bult and Seevinck, {P R} and Krijger, {G C} and T Visser and Kroon-Batenburg, {L M J} and Bakker, {C J G} and Hennink, {W E} and {van het Schip}, {A D} and Nijsen, {J F W}",
year = "2009",
month = "6",
doi = "10.1007/s11095-009-9848-8",
language = "English",
volume = "26",
pages = "1371--1378",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "SPRINGER/PLENUM PUBLISHERS",
number = "6",

}

RIS

TY - JOUR

T1 - Microspheres with ultrahigh holmium content for radioablation of malignancies

AU - Bult, W

AU - Seevinck, P R

AU - Krijger, G C

AU - Visser, T

AU - Kroon-Batenburg, L M J

AU - Bakker, C J G

AU - Hennink, W E

AU - van het Schip, A D

AU - Nijsen, J F W

PY - 2009/6

Y1 - 2009/6

N2 - PURPOSE: The aim of this study was to develop microspheres with an ultra high holmium content which can be neutron activated for radioablation of malignancies. These microspheres are proposed to be delivered selectively through either intratumoral injections into solid tumors or administered via an intravascularly placed catheter.METHODS: Microspheres were prepared by solvent evaporation, using holmium acetylacetonate (HoAcAc) crystals as the sole ingredient. Microspheres were characterized using light and scanning electron microscopy, coulter counter, titrimetry, infrared and Raman spectroscopy, differential scanning calorimetry, X-ray powder diffraction, magnetic resonance imaging (MRI), and X-ray computed tomography (CT).RESULTS: Microspheres, thus prepared displayed a smooth surface. The holmium content of the HoAcAc microspheres (44% (w/w)) was higher than the holmium content of the starting material, HoAcAc crystals (33% (w/w)). This was attributed to the loss of acetylacetonate from the HoAcAc complex, during rearrangement of acetylacetonate around the holmium ion. The increase of the holmium content allows for the detection of (sub)microgram amounts of microspheres using MRI and CT.CONCLUSIONS: HoAcAc microspheres with an ultra-high holmium content were prepared. These microspheres are suitable for radioablation of tumors by intratumoral injections or treatment of liver tumors through transcatheter administration.

AB - PURPOSE: The aim of this study was to develop microspheres with an ultra high holmium content which can be neutron activated for radioablation of malignancies. These microspheres are proposed to be delivered selectively through either intratumoral injections into solid tumors or administered via an intravascularly placed catheter.METHODS: Microspheres were prepared by solvent evaporation, using holmium acetylacetonate (HoAcAc) crystals as the sole ingredient. Microspheres were characterized using light and scanning electron microscopy, coulter counter, titrimetry, infrared and Raman spectroscopy, differential scanning calorimetry, X-ray powder diffraction, magnetic resonance imaging (MRI), and X-ray computed tomography (CT).RESULTS: Microspheres, thus prepared displayed a smooth surface. The holmium content of the HoAcAc microspheres (44% (w/w)) was higher than the holmium content of the starting material, HoAcAc crystals (33% (w/w)). This was attributed to the loss of acetylacetonate from the HoAcAc complex, during rearrangement of acetylacetonate around the holmium ion. The increase of the holmium content allows for the detection of (sub)microgram amounts of microspheres using MRI and CT.CONCLUSIONS: HoAcAc microspheres with an ultra-high holmium content were prepared. These microspheres are suitable for radioablation of tumors by intratumoral injections or treatment of liver tumors through transcatheter administration.

KW - Calorimetry, Differential Scanning

KW - Holmium

KW - Humans

KW - Hydroxybutyrates

KW - Liver Neoplasms

KW - Magnetic Resonance Imaging

KW - Microspheres

KW - Particle Size

KW - Pentanones

KW - Spectrum Analysis, Raman

KW - Surface Properties

KW - Tomography, X-Ray Computed

KW - X-Ray Diffraction

U2 - 10.1007/s11095-009-9848-8

DO - 10.1007/s11095-009-9848-8

M3 - Article

VL - 26

SP - 1371

EP - 1378

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 6

ER -

ID: 32629433