Publication

Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms

Sabogal-Guáqueta, A. M., Marmolejo-Garza, A., de Pádua, V. P., Eggen, B., Boddeke, E. & Dolga, A. M., Jul-2020, In : Progress in Neurobiology. 190, 17 p., 101805.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Sabogal-Guáqueta, A. M., Marmolejo-Garza, A., de Pádua, V. P., Eggen, B., Boddeke, E., & Dolga, A. M. (2020). Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms. Progress in Neurobiology, 190, [101805]. https://doi.org/10.1016/j.pneurobio.2020.101805

Author

Sabogal-Guáqueta, Angélica María ; Marmolejo-Garza, Alejandro ; de Pádua, Vítor Passos ; Eggen, Bart ; Boddeke, Erik ; Dolga, Amalia M. / Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms. In: Progress in Neurobiology. 2020 ; Vol. 190.

Harvard

Sabogal-Guáqueta, AM, Marmolejo-Garza, A, de Pádua, VP, Eggen, B, Boddeke, E & Dolga, AM 2020, 'Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms', Progress in Neurobiology, vol. 190, 101805. https://doi.org/10.1016/j.pneurobio.2020.101805

Standard

Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms. / Sabogal-Guáqueta, Angélica María; Marmolejo-Garza, Alejandro; de Pádua, Vítor Passos; Eggen, Bart; Boddeke, Erik; Dolga, Amalia M.

In: Progress in Neurobiology, Vol. 190, 101805, 07.2020.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Sabogal-Guáqueta AM, Marmolejo-Garza A, de Pádua VP, Eggen B, Boddeke E, Dolga AM. Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms. Progress in Neurobiology. 2020 Jul;190. 101805. https://doi.org/10.1016/j.pneurobio.2020.101805


BibTeX

@article{292ed5ea73de468a8d440c5ebc6ef9b8,
title = "Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms",
abstract = "Microglia are the main innate immune cells of the central nervous system (CNS). Unlike neurons and glial cells, which derive from ectoderm, microglia migrate early during embryo development from the yolk-sac, a mesodermal-derived structure. Microglia regulate synaptic pruning during development and induce or modulate inflammation during aging and chronic diseases. Microglia are sensitive to brain injuries and threats, altering their phenotype and function to adopt a so-called immune-activated state in response to any perceived threat to the CNS integrity. Here, we present a short overview on the role of microglia in human neurodegenerative diseases and provide an update on the current model systems to study microglia, including cell lines, iPSC-derived microglia with an emphasis in their transcriptomic profile and integration into 3D brain organoids. We present various strategies to model and study their role in neurodegeneration providing a relevant platform for the development of novel and more effective therapies.",
keywords = "Microglia, iPSC, Neurodegenerative diseases, Organoids, Transcriptomics, CENTRAL-NERVOUS-SYSTEM, ALZHEIMERS-DISEASE, PARKINSONS-DISEASE, BRAIN-DEVELOPMENT, MOUSE MODEL, MITOCHONDRIAL DYSFUNCTION, GENE-EXPRESSION, TAU PATHOLOGY, ACTIVATION, DIFFERENTIATION",
author = "Sabogal-Gu{\'a}queta, {Ang{\'e}lica Mar{\'i}a} and Alejandro Marmolejo-Garza and {de P{\'a}dua}, {V{\'i}tor Passos} and Bart Eggen and Erik Boddeke and Dolga, {Amalia M}",
note = "Copyright {\textcopyright} 2020. Published by Elsevier Ltd.",
year = "2020",
month = jul,
doi = "10.1016/j.pneurobio.2020.101805",
language = "English",
volume = "190",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms

AU - Sabogal-Guáqueta, Angélica María

AU - Marmolejo-Garza, Alejandro

AU - de Pádua, Vítor Passos

AU - Eggen, Bart

AU - Boddeke, Erik

AU - Dolga, Amalia M

N1 - Copyright © 2020. Published by Elsevier Ltd.

PY - 2020/7

Y1 - 2020/7

N2 - Microglia are the main innate immune cells of the central nervous system (CNS). Unlike neurons and glial cells, which derive from ectoderm, microglia migrate early during embryo development from the yolk-sac, a mesodermal-derived structure. Microglia regulate synaptic pruning during development and induce or modulate inflammation during aging and chronic diseases. Microglia are sensitive to brain injuries and threats, altering their phenotype and function to adopt a so-called immune-activated state in response to any perceived threat to the CNS integrity. Here, we present a short overview on the role of microglia in human neurodegenerative diseases and provide an update on the current model systems to study microglia, including cell lines, iPSC-derived microglia with an emphasis in their transcriptomic profile and integration into 3D brain organoids. We present various strategies to model and study their role in neurodegeneration providing a relevant platform for the development of novel and more effective therapies.

AB - Microglia are the main innate immune cells of the central nervous system (CNS). Unlike neurons and glial cells, which derive from ectoderm, microglia migrate early during embryo development from the yolk-sac, a mesodermal-derived structure. Microglia regulate synaptic pruning during development and induce or modulate inflammation during aging and chronic diseases. Microglia are sensitive to brain injuries and threats, altering their phenotype and function to adopt a so-called immune-activated state in response to any perceived threat to the CNS integrity. Here, we present a short overview on the role of microglia in human neurodegenerative diseases and provide an update on the current model systems to study microglia, including cell lines, iPSC-derived microglia with an emphasis in their transcriptomic profile and integration into 3D brain organoids. We present various strategies to model and study their role in neurodegeneration providing a relevant platform for the development of novel and more effective therapies.

KW - Microglia

KW - iPSC

KW - Neurodegenerative diseases

KW - Organoids

KW - Transcriptomics

KW - CENTRAL-NERVOUS-SYSTEM

KW - ALZHEIMERS-DISEASE

KW - PARKINSONS-DISEASE

KW - BRAIN-DEVELOPMENT

KW - MOUSE MODEL

KW - MITOCHONDRIAL DYSFUNCTION

KW - GENE-EXPRESSION

KW - TAU PATHOLOGY

KW - ACTIVATION

KW - DIFFERENTIATION

U2 - 10.1016/j.pneurobio.2020.101805

DO - 10.1016/j.pneurobio.2020.101805

M3 - Review article

C2 - 32335273

VL - 190

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

M1 - 101805

ER -

ID: 123660012