Publication

Microfiltration sampling in rats and in cows: toward a portable device for continuous glucocorticoid hormone sampling

Huinink, K. D., Lambooij, B., Jansen-van Zelm, K., Cremers, T. I. F. H., van Oeveren, W., Bakker, P. L., Venema, K., Westerink, B. H. C. & Korf, J., 2010, In : Analyst. 135, 2, p. 390-396 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Huinink, K. D., Lambooij, B., Jansen-van Zelm, K., Cremers, T. I. F. H., van Oeveren, W., Bakker, P. L., ... Korf, J. (2010). Microfiltration sampling in rats and in cows: toward a portable device for continuous glucocorticoid hormone sampling. Analyst, 135(2), 390-396. https://doi.org/10.1039/b921629d

Author

Huinink, Kirsten D. ; Lambooij, Bert ; Jansen-van Zelm, Karola ; Cremers, Thomas I. F. H. ; van Oeveren, Wim ; Bakker, Petra L. ; Venema, Kor ; Westerink, Ben H. C. ; Korf, Jakob. / Microfiltration sampling in rats and in cows : toward a portable device for continuous glucocorticoid hormone sampling. In: Analyst. 2010 ; Vol. 135, No. 2. pp. 390-396.

Harvard

Huinink, KD, Lambooij, B, Jansen-van Zelm, K, Cremers, TIFH, van Oeveren, W, Bakker, PL, Venema, K, Westerink, BHC & Korf, J 2010, 'Microfiltration sampling in rats and in cows: toward a portable device for continuous glucocorticoid hormone sampling', Analyst, vol. 135, no. 2, pp. 390-396. https://doi.org/10.1039/b921629d

Standard

Microfiltration sampling in rats and in cows : toward a portable device for continuous glucocorticoid hormone sampling. / Huinink, Kirsten D.; Lambooij, Bert; Jansen-van Zelm, Karola; Cremers, Thomas I. F. H.; van Oeveren, Wim; Bakker, Petra L.; Venema, Kor; Westerink, Ben H. C.; Korf, Jakob.

In: Analyst, Vol. 135, No. 2, 2010, p. 390-396.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Huinink KD, Lambooij B, Jansen-van Zelm K, Cremers TIFH, van Oeveren W, Bakker PL et al. Microfiltration sampling in rats and in cows: toward a portable device for continuous glucocorticoid hormone sampling. Analyst. 2010;135(2):390-396. https://doi.org/10.1039/b921629d


BibTeX

@article{3a1b6288a86f43d8b49961af168d4c95,
title = "Microfiltration sampling in rats and in cows: toward a portable device for continuous glucocorticoid hormone sampling",
abstract = "To monitor temporal patterns of glucocorticoids hormones in living animals, most often blood samples are collected. Blood sampling is invasive and subjects may find it - in particular - unpleasant when multiple samples are collected. We have developed a microfiltration collection device (MCD) sampling continuously, pulse-free, over a selected period of time, with minimum invasiveness as the device is inserted with only one venipuncture. The MCD consists of a hollow fiber membrane (probe), capillary collection coil and flow creator. Three biocompatible hollow fiber membranes were assessed on flow rate in rats, by placing the probe intraperitoneally, subcutaneously, or intravascularly and with or without heparin coating. The probe made from polyethylene coated with ethylene vinyl alcohol heparin conveyed the best results and had the most benefit of the heparin coating. Consequently this probe was built into a collection device and tested in cows, sampling blood microfiltrate. Cortisol (protein-bound and-free) could be monitored in cows over a period of 7 hours. This device has several major advantages compared to manual blood collection: minor stress is induced by the application of the device; it has a low weight and can therefore be used in freely active subjects being in their own surroundings. The device can be sterilized and manufactured as a disposable tool, and the filled MCD can be shipped by regular mail to a specialized laboratory facility for analysis.",
keywords = "MASS-SPECTROMETRIC PROTEOMICS, CAPILLARY ULTRAFILTRATION PROBES, IN-VIVO, INTERSTITIAL FLUID, MICRODIALYSIS, LACTATE, GLUCOSE, PROTEINS, BRAIN, PHARMACOKINETICS",
author = "Huinink, {Kirsten D.} and Bert Lambooij and {Jansen-van Zelm}, Karola and Cremers, {Thomas I. F. H.} and {van Oeveren}, Wim and Bakker, {Petra L.} and Kor Venema and Westerink, {Ben H. C.} and Jakob Korf",
year = "2010",
doi = "10.1039/b921629d",
language = "English",
volume = "135",
pages = "390--396",
journal = "Analyst",
issn = "0003-2654",
number = "2",

}

RIS

TY - JOUR

T1 - Microfiltration sampling in rats and in cows

T2 - toward a portable device for continuous glucocorticoid hormone sampling

AU - Huinink, Kirsten D.

AU - Lambooij, Bert

AU - Jansen-van Zelm, Karola

AU - Cremers, Thomas I. F. H.

AU - van Oeveren, Wim

AU - Bakker, Petra L.

AU - Venema, Kor

AU - Westerink, Ben H. C.

AU - Korf, Jakob

PY - 2010

Y1 - 2010

N2 - To monitor temporal patterns of glucocorticoids hormones in living animals, most often blood samples are collected. Blood sampling is invasive and subjects may find it - in particular - unpleasant when multiple samples are collected. We have developed a microfiltration collection device (MCD) sampling continuously, pulse-free, over a selected period of time, with minimum invasiveness as the device is inserted with only one venipuncture. The MCD consists of a hollow fiber membrane (probe), capillary collection coil and flow creator. Three biocompatible hollow fiber membranes were assessed on flow rate in rats, by placing the probe intraperitoneally, subcutaneously, or intravascularly and with or without heparin coating. The probe made from polyethylene coated with ethylene vinyl alcohol heparin conveyed the best results and had the most benefit of the heparin coating. Consequently this probe was built into a collection device and tested in cows, sampling blood microfiltrate. Cortisol (protein-bound and-free) could be monitored in cows over a period of 7 hours. This device has several major advantages compared to manual blood collection: minor stress is induced by the application of the device; it has a low weight and can therefore be used in freely active subjects being in their own surroundings. The device can be sterilized and manufactured as a disposable tool, and the filled MCD can be shipped by regular mail to a specialized laboratory facility for analysis.

AB - To monitor temporal patterns of glucocorticoids hormones in living animals, most often blood samples are collected. Blood sampling is invasive and subjects may find it - in particular - unpleasant when multiple samples are collected. We have developed a microfiltration collection device (MCD) sampling continuously, pulse-free, over a selected period of time, with minimum invasiveness as the device is inserted with only one venipuncture. The MCD consists of a hollow fiber membrane (probe), capillary collection coil and flow creator. Three biocompatible hollow fiber membranes were assessed on flow rate in rats, by placing the probe intraperitoneally, subcutaneously, or intravascularly and with or without heparin coating. The probe made from polyethylene coated with ethylene vinyl alcohol heparin conveyed the best results and had the most benefit of the heparin coating. Consequently this probe was built into a collection device and tested in cows, sampling blood microfiltrate. Cortisol (protein-bound and-free) could be monitored in cows over a period of 7 hours. This device has several major advantages compared to manual blood collection: minor stress is induced by the application of the device; it has a low weight and can therefore be used in freely active subjects being in their own surroundings. The device can be sterilized and manufactured as a disposable tool, and the filled MCD can be shipped by regular mail to a specialized laboratory facility for analysis.

KW - MASS-SPECTROMETRIC PROTEOMICS

KW - CAPILLARY ULTRAFILTRATION PROBES

KW - IN-VIVO

KW - INTERSTITIAL FLUID

KW - MICRODIALYSIS

KW - LACTATE

KW - GLUCOSE

KW - PROTEINS

KW - BRAIN

KW - PHARMACOKINETICS

U2 - 10.1039/b921629d

DO - 10.1039/b921629d

M3 - Article

VL - 135

SP - 390

EP - 396

JO - Analyst

JF - Analyst

SN - 0003-2654

IS - 2

ER -

ID: 5020116