Micro-computed tomography (micro-CT) for intraoperative surgical margin assessment of breast cancer: A feasibility study in breast conserving surgeryQiu, S-Q., Dorrius, M. D., de Jongh, S. J., Jansen, L., de Vries, J., Schröder, C. P., Zhang, G-J., de Vries, E. G. E., van der Vegt, B. & van Dam, G. M., Nov-2018, In : European Journal of Surgical Oncology. 44, 11, p. 1708-1713 6 p.
Research output: Contribution to journal › Article › Academic › peer-review
Purpose: Around 15%-30% of patients receiving breast-conserving surgery (BCS) for invasive breast carcinoma or ductal carcinoma in situ (DCIS) need a reoperation due to tumor-positive margins at final histopathology. Currently available intraoperative surgical margin assessment modalities all have specific limitations. Therefore, we aimed to assess the feasibility and accuracy of micro-computed tomography (micro-CT) as a novel method for intraoperative margin assessment in BCS.
Methods: Lumpectomy specimens from 30 consecutive patients diagnosed with invasive breast cancer or DCIS were imaged using a micro-CT. Margin status was assessed on micro-CT images by two investigators who were blinded to the final histopathological margin status. The micro-CT margin status was compared with the histopathological margin status.
Results: The margin status could be assessed by micro-CT in 29 out of 30 patients. Of these, nine patients had a positive tumor margin and 20 a negative tumor margin at final histopathology. Margin status evaluation by micro-CT took always less than 15 min. The margin status in 25 patients was correctly predicted by micro-CT. There were four false-negative predictions. The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of micro-CT in margin status prediction were 86%, 56%, 100%, 100% and 83%, respectively. With micro-CT, the positive margin rate could potentially have been reduced from 31% to 14%.
Conclusions: Whole lumpectomy specimen micro-CT scanning is a promising technique for intraoperative margin assessment in BCS. lntraoperative quick feedback on the margin status could potentially lead to a reduction in the number of reoperations. (C) 2018 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
|Number of pages||6|
|Journal||European Journal of Surgical Oncology|
|Publication status||Published - Nov-2018|
- Micro-CT, Breast cancer, Breast-conserving surgery, Surgical margin assessment, FROZEN-SECTION ANALYSIS, ADJUVANT BREAST, CONSERVATION, RATES, MANAGEMENT, CARCINOMA, ACCURACY, EXCISION, UPDATE