Publication

Microbiome to Brain: Unravelling the Multidirectional Axes of Communication

El Aidy, S., Stilling, R., Dinan, T. G. & Cryan, J. F., 2016, Microbial Endocrinology: Interkingdom Signalling in Infectious Diseases and Health. Lyte, M. (ed.). 2 ed. Springer International Publishing AG, Vol. 874. p. 301-336 36 p. (Advances in Experimental Medicine and Biology; vol. 874).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Copy link to clipboard

Documents

  • Microbiome to Brain_BookChapter_El Aidy et al_2015

    Final publisher's version, 697 KB, PDF document

    Request copy

DOI

The gut microbiome plays a crucial role in host physiology. Disruption of its community structure and function can have wide-ranging effects making it critical to understand exactly how the interactive dialogue between the host and its microbiota is regulated to maintain homeostasis. An array of multidirectional signalling molecules is clearly involved in the host-microbiome communication. This interactive signalling not only impacts the gastrointestinal tract, where the majority of microbiota resides, but also extends to affect other host systems including the brain and liver as well as the microbiome itself. Understanding the mechanistic principles of this inter-kingdom signalling is fundamental to unravelling how our supraorganism function to maintain wellbeing, subsequently opening up new avenues for microbiome manipulation to favour desirable mental health outcome.

Original languageEnglish
Title of host publicationMicrobial Endocrinology
Subtitle of host publicationInterkingdom Signalling in Infectious Diseases and Health
EditorsMark Lyte
PublisherSpringer International Publishing AG
Pages301-336
Number of pages36
Volume874
Edition2
ISBN (Electronic)978-3-319-20215-0
ISBN (Print)978-3-319-20214-3
Publication statusPublished - 2016

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSPRINGER INTERNATIONAL PUBLISHING AG
Volume874
ISSN (Print)0065-2598

    Keywords

  • Microbiota, Gut-brain axis, Immune system, Metabolites, Epigenetics, AUTISM SPECTRUM DISORDERS, LONG NONCODING RNAS, IRRITABLE-BOWEL-SYNDROME, HUMAN GUT MICROBIOME, PROBIOTIC BIFIDOBACTERIUM-INFANTIS, HISTONE DEACETYLASE INHIBITOR, ENTERIC NERVOUS-SYSTEM, CHAIN FATTY-ACIDS, INTESTINAL MICROBIOTA, IMMUNE-SYSTEM

ID: 30657462