Microbiome to Brain: Unravelling the Multidirectional Axes of CommunicationEl Aidy, S., Stilling, R., Dinan, T. G. & Cryan, J. F., 2016, Microbial Endocrinology: Interkingdom Signalling in Infectious Diseases and Health. Lyte, M. (ed.). 2 ed. Springer International Publishing AG, Vol. 874. p. 301-336 36 p. (Advances in Experimental Medicine and Biology; vol. 874).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
The gut microbiome plays a crucial role in host physiology. Disruption of its community structure and function can have wide-ranging effects making it critical to understand exactly how the interactive dialogue between the host and its microbiota is regulated to maintain homeostasis. An array of multidirectional signalling molecules is clearly involved in the host-microbiome communication. This interactive signalling not only impacts the gastrointestinal tract, where the majority of microbiota resides, but also extends to affect other host systems including the brain and liver as well as the microbiome itself. Understanding the mechanistic principles of this inter-kingdom signalling is fundamental to unravelling how our supraorganism function to maintain wellbeing, subsequently opening up new avenues for microbiome manipulation to favour desirable mental health outcome.
|Title of host publication||Microbial Endocrinology|
|Subtitle of host publication||Interkingdom Signalling in Infectious Diseases and Health|
|Publisher||Springer International Publishing AG|
|Number of pages||36|
|Publication status||Published - 2016|
|Name||Advances in Experimental Medicine and Biology|
|Publisher||SPRINGER INTERNATIONAL PUBLISHING AG|
- Microbiota, Gut-brain axis, Immune system, Metabolites, Epigenetics, AUTISM SPECTRUM DISORDERS, LONG NONCODING RNAS, IRRITABLE-BOWEL-SYNDROME, HUMAN GUT MICROBIOME, PROBIOTIC BIFIDOBACTERIUM-INFANTIS, HISTONE DEACETYLASE INHIBITOR, ENTERIC NERVOUS-SYSTEM, CHAIN FATTY-ACIDS, INTESTINAL MICROBIOTA, IMMUNE-SYSTEM