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Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification

Kuipers, F., de Boer, J. F. & Staels, B., 3-Mar-2020, In : Cell metabolism. 31, 3, p. 445-447 3 p.

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  • Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification

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DOI

The microbiome is well known to influence the immune response of the host. Song et al. now show that the microbiome modulates adaptive immunity in mice through formation of bile acid species acting on ROR gamma(+) regulatory T cells via the Vitamin D Receptor, thereby lowering the vulnerability for chemically induced colitis.

Original languageEnglish
Pages (from-to)445-447
Number of pages3
JournalCell metabolism
Volume31
Issue number3
Publication statusPublished - 3-Mar-2020

    Keywords

  • DEFICIENT, RECEPTOR, SALTS, MICE

ID: 119779275