Microbiome Modulation of the Host Adaptive Immunity through Bile Acid ModificationKuipers, F., de Boer, J. F. & Staels, B., 3-Mar-2020, In : Cell metabolism. 31, 3, p. 445-447 3 p.
Research output: Contribution to journal › Editorial › Academic › peer-review
The microbiome is well known to influence the immune response of the host. Song et al. now show that the microbiome modulates adaptive immunity in mice through formation of bile acid species acting on RORγ+ regulatory T cells via the Vitamin D Receptor, thereby lowering the vulnerability for chemically induced colitis.
|Number of pages||3|
|Publication status||Published - 3-Mar-2020|
- DEFICIENT, RECEPTOR, SALTS, MICE