Publication

Microalbuminuria and endothelial dysfunction: Emerging targets for primary prevention of end-organ damage

Ochodnicky, P., Henning, R. H., van Dokkum, R. P. E. & de Zeeuw, D., 2006, In : Journal of Cardiovascular Pharmacology. 47, p. S151-S162 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

A minor increase in urinary albumin excretion (microalbuminuria) is known to predict adverse renal and cardiovascular events in diabetic and hypertensive patients. Recent intriguing findings show that microalbuminuria is an early and sensitive marker of future cardiovascular events even in healthy subjects. The mechanisms linking microalbuminuria with end-organ damage have not been fully explained yet; however, generalized endothelial dysfunction might play an important role. Prevailing experimental and clinical data suggest that generalized endothelial dysfunction, frequently characterized by decreased nitric oxide bioavailability, actually precedes the development of microalbuminuria. This review summarizes the current knowledge about the intricate relationship between microalbuminuria and endothelial dysfunction. On the basis of the current evidence, we propose that microalbuminuria and endothelial dysfunction are an emerging target for primary prevention strategies in cardiovascular disease. In near future, dietary components improving nitric oxide bioavailability, such as cocoa-derived flavanols may play important role in these preventive strategies.

Original languageEnglish
Pages (from-to)S151-S162
Number of pages12
JournalJournal of Cardiovascular Pharmacology
Volume47
Publication statusPublished - 2006
EventConference on Cocoa Flavanols and Cardiovascular Function - , Switzerland
Duration: 25-Jul-200526-Jul-2005

Event

Conference on Cocoa Flavanols and Cardiovascular Function

25/07/200526/07/2005

Switzerland

Event: Other

    Keywords

  • microalbuminuria, endothelial dysfunction, cardiovascular disease, primary prevention, predictive value, cocoa, flavanols, URINARY ALBUMIN EXCRETION, DEPENDENT DIABETES-MELLITUS, CORONARY-HEART-DISEASE, CLINICALLY HEALTHY-SUBJECTS, CELL-ADHESION MOLECULE-1, VON-WILLEBRAND-FACTOR, STAGE RENAL-DISEASE, LEFT-VENTRICULAR HYPERTROPHY, FLOW-MEDIATED VASODILATION, TRANSCAPILLARY ESCAPE RATE

ID: 4451955