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Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study

Du, Y., Zhao, Y., Sidorenkov, G., de Bock, G. H., Cui, X., Huang, Y., Dorrius, M. D., Rook, M., Groen, H. J. M., Heuvelmans, M. A., Vliegenthart, R., Chen, K., Xie, X., Liu, S., Oudkerk, M. & Ye, Z., Feb-2019, In : Cancer biology & medicine. 16, 1, p. 181-188 8 p.

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  • Methods of computed tomography screening and management of lung cancer in Tianjin

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DOI

Objective: European lung cancer screening studies using computed tomography (CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time (VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.

Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol (Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT (a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.

Results: The diagnostic performance of volume- and diameter-based management for lung nodules in a Chinese population will be estimated and compared.

Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalCancer biology & medicine
Volume16
Issue number1
Publication statusPublished - Feb-2019

    Keywords

  • Lung cancer, lung nodules, screening, computed tomography, China, PULMONARY SUBSOLID NODULES, MORTALITY, EPIDEMIOLOGY, PROBABILITY, STATEMENT, FEATURES, VOLUME, CHINA

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