Publication

Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis

Reitsema, V. A., Star, B. S., de Jager, V. D., van Meurs, M., Henning, R. H. & Bouma, H. R., 10-Jul-2019, In : Antioxidants & Redox Signaling. 31, 2, p. 134-152 19 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Reitsema, V. A., Star, B. S., de Jager, V. D., van Meurs, M., Henning, R. H., & Bouma, H. R. (2019). Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis. Antioxidants & Redox Signaling, 31(2), 134-152. https://doi.org/10.1089/ars.2018.7537

Author

Reitsema, Vera A ; Star, Bastiaan S ; de Jager, Vincent D ; van Meurs, Matijs ; Henning, Robert H ; Bouma, Hjalmar R. / Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis. In: Antioxidants & Redox Signaling. 2019 ; Vol. 31, No. 2. pp. 134-152.

Harvard

Reitsema, VA, Star, BS, de Jager, VD, van Meurs, M, Henning, RH & Bouma, HR 2019, 'Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis' Antioxidants & Redox Signaling, vol. 31, no. 2, pp. 134-152. https://doi.org/10.1089/ars.2018.7537

Standard

Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis. / Reitsema, Vera A; Star, Bastiaan S; de Jager, Vincent D; van Meurs, Matijs; Henning, Robert H; Bouma, Hjalmar R.

In: Antioxidants & Redox Signaling, Vol. 31, No. 2, 10.07.2019, p. 134-152.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Reitsema VA, Star BS, de Jager VD, van Meurs M, Henning RH, Bouma HR. Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis. Antioxidants & Redox Signaling. 2019 Jul 10;31(2):134-152. https://doi.org/10.1089/ars.2018.7537


BibTeX

@article{b93dfc16f4334a29bc660d04181067bd,
title = "Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis",
abstract = "Recent Advances: Mitochondrial dysfunction is emerging as a key process in the induction of organ dysfunction during sepsis, and metabolic resuscitation might reveal to be a novel cornerstone in the treatment of sepsis. Critical Issues: Here, we review novel strategies to maintain organ function in sepsis by precluding mitochondrial dysfunction by lowering energetic demand to allow preservation of adenosine triphosphate-levels, while reducing free radical generation. As the most common strategy to suppress metabolism, that is, cooling, does not reveal unequivocal beneficial effects and may even increase mortality, caloric restriction or modulation of energy-sensing pathways (i.e., sirtuins and AMP-activated protein kinase) may offer safe alternatives. Similar effects may be offered when mimicking hibernation by hydrogen sulfide (H2S). In addition H2S may also confer beneficial effects through upregulation of antioxidant mechanisms, similar to the other gasotransmitters nitric oxide and carbon monoxide, which display antioxidant and anti-inflammatory effects in sepsis. In addition, oxidative stress may be averted by systemic or mitochondria-targeted antioxidants, of which a wide range are able to lower inflammation, as well as reduce organ dysfunction and mortality from sepsis. Future Directions: Mitochondrial dysfunction plays a key role in the pathophysiology of sepsis. As a consequence, metabolic resuscitation might reveal to be a novel cornerstone in the treatment of sepsis.",
keywords = "sepsis, oxidative phosphorylation, metabolism, hypothermia, caloric restriction, hibernation, hydrogen sulfide, ALPHA-LIPOIC ACID, ACUTE KIDNEY INJURY, PERMEABLE RADICAL SCAVENGER, CARBON-MONOXIDE INHALATION, CRITICALLY-ILL PATIENTS, PROTEIN-KINASE PATHWAY, NITRIC-OXIDE, SEPTIC SHOCK, OXIDATIVE STRESS, RAT MODEL",
author = "Reitsema, {Vera A} and Star, {Bastiaan S} and {de Jager}, {Vincent D} and {van Meurs}, Matijs and Henning, {Robert H} and Bouma, {Hjalmar R}",
year = "2019",
month = "7",
day = "10",
doi = "10.1089/ars.2018.7537",
language = "English",
volume = "31",
pages = "134--152",
journal = "Antioxidants & Redox Signaling",
issn = "1523-0864",
publisher = "MARY ANN LIEBERT, INC",
number = "2",

}

RIS

TY - JOUR

T1 - Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis

AU - Reitsema, Vera A

AU - Star, Bastiaan S

AU - de Jager, Vincent D

AU - van Meurs, Matijs

AU - Henning, Robert H

AU - Bouma, Hjalmar R

PY - 2019/7/10

Y1 - 2019/7/10

N2 - Recent Advances: Mitochondrial dysfunction is emerging as a key process in the induction of organ dysfunction during sepsis, and metabolic resuscitation might reveal to be a novel cornerstone in the treatment of sepsis. Critical Issues: Here, we review novel strategies to maintain organ function in sepsis by precluding mitochondrial dysfunction by lowering energetic demand to allow preservation of adenosine triphosphate-levels, while reducing free radical generation. As the most common strategy to suppress metabolism, that is, cooling, does not reveal unequivocal beneficial effects and may even increase mortality, caloric restriction or modulation of energy-sensing pathways (i.e., sirtuins and AMP-activated protein kinase) may offer safe alternatives. Similar effects may be offered when mimicking hibernation by hydrogen sulfide (H2S). In addition H2S may also confer beneficial effects through upregulation of antioxidant mechanisms, similar to the other gasotransmitters nitric oxide and carbon monoxide, which display antioxidant and anti-inflammatory effects in sepsis. In addition, oxidative stress may be averted by systemic or mitochondria-targeted antioxidants, of which a wide range are able to lower inflammation, as well as reduce organ dysfunction and mortality from sepsis. Future Directions: Mitochondrial dysfunction plays a key role in the pathophysiology of sepsis. As a consequence, metabolic resuscitation might reveal to be a novel cornerstone in the treatment of sepsis.

AB - Recent Advances: Mitochondrial dysfunction is emerging as a key process in the induction of organ dysfunction during sepsis, and metabolic resuscitation might reveal to be a novel cornerstone in the treatment of sepsis. Critical Issues: Here, we review novel strategies to maintain organ function in sepsis by precluding mitochondrial dysfunction by lowering energetic demand to allow preservation of adenosine triphosphate-levels, while reducing free radical generation. As the most common strategy to suppress metabolism, that is, cooling, does not reveal unequivocal beneficial effects and may even increase mortality, caloric restriction or modulation of energy-sensing pathways (i.e., sirtuins and AMP-activated protein kinase) may offer safe alternatives. Similar effects may be offered when mimicking hibernation by hydrogen sulfide (H2S). In addition H2S may also confer beneficial effects through upregulation of antioxidant mechanisms, similar to the other gasotransmitters nitric oxide and carbon monoxide, which display antioxidant and anti-inflammatory effects in sepsis. In addition, oxidative stress may be averted by systemic or mitochondria-targeted antioxidants, of which a wide range are able to lower inflammation, as well as reduce organ dysfunction and mortality from sepsis. Future Directions: Mitochondrial dysfunction plays a key role in the pathophysiology of sepsis. As a consequence, metabolic resuscitation might reveal to be a novel cornerstone in the treatment of sepsis.

KW - sepsis

KW - oxidative phosphorylation

KW - metabolism

KW - hypothermia

KW - caloric restriction

KW - hibernation

KW - hydrogen sulfide

KW - ALPHA-LIPOIC ACID

KW - ACUTE KIDNEY INJURY

KW - PERMEABLE RADICAL SCAVENGER

KW - CARBON-MONOXIDE INHALATION

KW - CRITICALLY-ILL PATIENTS

KW - PROTEIN-KINASE PATHWAY

KW - NITRIC-OXIDE

KW - SEPTIC SHOCK

KW - OXIDATIVE STRESS

KW - RAT MODEL

U2 - 10.1089/ars.2018.7537

DO - 10.1089/ars.2018.7537

M3 - Review article

VL - 31

SP - 134

EP - 152

JO - Antioxidants & Redox Signaling

JF - Antioxidants & Redox Signaling

SN - 1523-0864

IS - 2

ER -

ID: 76330550