Publication

Metabolic niche adaptation of community- and hospital-associated methicillin-resistant Staphylococcus aureus

Mekonnen, S. A., Palma Medina, L. M., Michalik, S., Loreti, M. G., Gesell Salazar, M., van Dijl, J. M. & Völker, U., 20-Feb-2019, In : Journal of proteomics. 193, p. 154-161 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Metabolic niche adaptation of community- and hospital-associated methicillin-resistant Staphylococcus aureus

    Final publisher's version, 5 MB, PDF-document

    Request copy

DOI

Methicillin-resistant Staphylococcus aureus (MRSA) originally emerged in nosocomial settings and has subsequently spread into the community. In turn, community-associated (CA) MRSA lineages are nowadays introduced from the community into hospitals where they can cause hospital-associated (HA) infections. This raises the question of how the CA-MRSA lineages adapt to the hospital environment. Previous studies implicated particular virulence factors in the CA-behaviour of MRSA. However, we hypothesized that physiological changes may also impact staphylococcal epidemiology. With the aim to identify potential metabolic adaptations, we comparatively profiled the cytosolic proteomes of CA- and HA-isolates from the USA300 lineage that was originally identified as CA-MRSA. Interestingly, enzymes for gluconeogenesis, the tricarboxylic acid cycle and biosynthesis of amino acids are up-regulated in the investigated CA-MRSA isolates, while enzymes for glycolysis and the pentose phosphate pathway are up-regulated in the HA-MRSA isolates. Of note, these data apparently match with the clinical presentation of each group. These observations spark interest in central carbon metabolism as a key driver for adaptations that streamline MRSA for propagation in the community or the hospital.

Original languageEnglish
Pages (from-to)154-161
Number of pages8
JournalJournal of proteomics
Volume193
Publication statusPublished - 20-Feb-2019

View graph of relations

ID: 77424490