Publication

Metabolic heterogeneity in clonal microbial populations

Takhaveev, V. & Heinemann, M., Oct-2018, In : Current Opinion in Microbiology. 45, p. 30-38 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Takhaveev, V., & Heinemann, M. (2018). Metabolic heterogeneity in clonal microbial populations. Current Opinion in Microbiology, 45, 30-38. https://doi.org/10.1016/j.mib.2018.02.004

Author

Takhaveev, Vakil ; Heinemann, Matthias. / Metabolic heterogeneity in clonal microbial populations. In: Current Opinion in Microbiology. 2018 ; Vol. 45. pp. 30-38.

Harvard

Takhaveev, V & Heinemann, M 2018, 'Metabolic heterogeneity in clonal microbial populations', Current Opinion in Microbiology, vol. 45, pp. 30-38. https://doi.org/10.1016/j.mib.2018.02.004

Standard

Metabolic heterogeneity in clonal microbial populations. / Takhaveev, Vakil; Heinemann, Matthias.

In: Current Opinion in Microbiology, Vol. 45, 10.2018, p. 30-38.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Takhaveev V, Heinemann M. Metabolic heterogeneity in clonal microbial populations. Current Opinion in Microbiology. 2018 Oct;45:30-38. https://doi.org/10.1016/j.mib.2018.02.004


BibTeX

@article{9474a9b7a00c41fea3cf365142f516c0,
title = "Metabolic heterogeneity in clonal microbial populations",
abstract = "In the past decades, numerous instances of phenotypic diversity were observed in clonal microbial populations, particularly, on the gene expression level. Much less is, however, known about phenotypic differences that occur on the level of metabolism. This is likely explained by the fact that experimental tools probing metabolism of single cells are still at an early stage of development. Here, we review recent exciting discoveries that point out different causes for metabolic heterogeneity within clonal microbial populations. These causes range from ecological factors and cell-inherent dynamics in constant environments to molecular noise in gene expression that propagates into metabolism. Furthermore, we provide an overview of current methods to quantify the levels of metabolites and biomass components in single cells.",
keywords = "Journal Article, Review",
author = "Vakil Takhaveev and Matthias Heinemann",
note = "Copyright {\circledC} 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2018",
month = "10",
doi = "10.1016/j.mib.2018.02.004",
language = "English",
volume = "45",
pages = "30--38",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",
publisher = "CURRENT BIOLOGY LTD",

}

RIS

TY - JOUR

T1 - Metabolic heterogeneity in clonal microbial populations

AU - Takhaveev, Vakil

AU - Heinemann, Matthias

N1 - Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2018/10

Y1 - 2018/10

N2 - In the past decades, numerous instances of phenotypic diversity were observed in clonal microbial populations, particularly, on the gene expression level. Much less is, however, known about phenotypic differences that occur on the level of metabolism. This is likely explained by the fact that experimental tools probing metabolism of single cells are still at an early stage of development. Here, we review recent exciting discoveries that point out different causes for metabolic heterogeneity within clonal microbial populations. These causes range from ecological factors and cell-inherent dynamics in constant environments to molecular noise in gene expression that propagates into metabolism. Furthermore, we provide an overview of current methods to quantify the levels of metabolites and biomass components in single cells.

AB - In the past decades, numerous instances of phenotypic diversity were observed in clonal microbial populations, particularly, on the gene expression level. Much less is, however, known about phenotypic differences that occur on the level of metabolism. This is likely explained by the fact that experimental tools probing metabolism of single cells are still at an early stage of development. Here, we review recent exciting discoveries that point out different causes for metabolic heterogeneity within clonal microbial populations. These causes range from ecological factors and cell-inherent dynamics in constant environments to molecular noise in gene expression that propagates into metabolism. Furthermore, we provide an overview of current methods to quantify the levels of metabolites and biomass components in single cells.

KW - Journal Article

KW - Review

U2 - 10.1016/j.mib.2018.02.004

DO - 10.1016/j.mib.2018.02.004

M3 - Review article

C2 - 29477028

VL - 45

SP - 30

EP - 38

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

ER -

ID: 54907035