Publication

Metabolic Effects of Bile Acids in the Gut in Health and Disease

Boesjes, M. & Brufau Dones, G., 2014, In : CURRENT MEDICINAL CHEMISTRY. 21, 24, p. 2822-2829 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

In the last decade, it became clear that bile acids, in addition to their role in intestinal absorption of lipids and fat-soluble vitamins, are major regulators of metabolism. They activate signal transduction pathways through binding to the specific bile acid receptors TGR5 and FXR. Indirectly, bile acids influence metabolism via modification of the gut microbiota ecosystem. The relation between bile acid metabolism and gut microbiota composition is very complex whereas gut microbiota modulates bile acid structure, creating a complex bile acid pool consisting of a mixture of differentially structured species, bile acids alter gut microbiota by disturbing bacterial membrane integrity. In addition, to the effects on glucose and energy homeostasis, recent literature ascribed a role for bile acid signaling in control of inflammation and regulation of the nervous system. In this review, we discuss a selection of recent published studies describing the effects of intestinal bile acid signaling on health and disease.

Original languageEnglish
Pages (from-to)2822-2829
Number of pages8
JournalCURRENT MEDICINAL CHEMISTRY
Volume21
Issue number24
Publication statusPublished - 2014

    Keywords

  • Bile acids, gut, microbiota, GLUCAGON-LIKE PEPTIDE-1, FARNESOID-X-RECEPTOR, 12-ALPHA-HYDROXYLASE GENE CYP8B1, STEROL 27-HYDROXYLASE GENE, SULFATE-REDUCING BACTERIA, NUCLEAR FACTOR 4-ALPHA, DIET-INDUCED OBESITY, ENERGY-EXPENDITURE, BILOPHILA-WADSWORTHIA, IMPROVED GLUCOSE

ID: 16337386