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Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids

van de Peppel, I. P., Verkade, H. J. & Jonker, J. W., 16-Sep-2020, In : American Journal of Physiology. Gastrointestinal and Liver Physiology. 28 p.

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  • Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids

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DOI

The enterohepatic circulation of bile acids comprises a tightly regulated process of hepatic bile acid secretion, intestinal reabsorption and transport back to the liver. Disruption of this process has significant consequences for both gastrointestinal, liver and whole-body homeostasis and therefore offers opportunities for therapeutic intervention. In this review we discuss the effects of (pharmacological) interruption of the enterohepatic circulation at different levels. Recently, several studies have been published on ileal interruption of the enterohepatic circulation of bile acids, targeting the apical-sodium dependent bile acid transporter (ASBT, SLC10A2), as therapy for various diseases. However, ambiguous results have been reported and in-depth mechanistic insights are lacking. Here we discuss these novel studies and review the current knowledge and literature on the consequences of ASBT inhibition and its potential effects on physiology and metabolism.

Original languageEnglish
Number of pages28
JournalAmerican Journal of Physiology. Gastrointestinal and Liver Physiology
Publication statusE-pub ahead of print - 16-Sep-2020

ID: 134509332