Publication

Mesodermal Gene Expression in the Acoel Isodiametra pulchra Indicates a Low Number of Mesodermal Cell Types and the Endomesodermal Origin of the Gonads

Chiodin, M., Borve, A., Berezikov, E., Ladurner, P., Martinez, P. & Hejnol, A., 6-Feb-2013, In : PLoS ONE. 8, 2, 15 p., e55499.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Chiodin, M., Borve, A., Berezikov, E., Ladurner, P., Martinez, P., & Hejnol, A. (2013). Mesodermal Gene Expression in the Acoel Isodiametra pulchra Indicates a Low Number of Mesodermal Cell Types and the Endomesodermal Origin of the Gonads. PLoS ONE, 8(2), [e55499]. https://doi.org/10.1371/journal.pone.0055499

Author

Chiodin, Marta ; Borve, Aina ; Berezikov, Eugene ; Ladurner, Peter ; Martinez, Pedro ; Hejnol, Andreas. / Mesodermal Gene Expression in the Acoel Isodiametra pulchra Indicates a Low Number of Mesodermal Cell Types and the Endomesodermal Origin of the Gonads. In: PLoS ONE. 2013 ; Vol. 8, No. 2.

Harvard

Chiodin, M, Borve, A, Berezikov, E, Ladurner, P, Martinez, P & Hejnol, A 2013, 'Mesodermal Gene Expression in the Acoel Isodiametra pulchra Indicates a Low Number of Mesodermal Cell Types and the Endomesodermal Origin of the Gonads', PLoS ONE, vol. 8, no. 2, e55499. https://doi.org/10.1371/journal.pone.0055499

Standard

Mesodermal Gene Expression in the Acoel Isodiametra pulchra Indicates a Low Number of Mesodermal Cell Types and the Endomesodermal Origin of the Gonads. / Chiodin, Marta; Borve, Aina; Berezikov, Eugene; Ladurner, Peter; Martinez, Pedro; Hejnol, Andreas.

In: PLoS ONE, Vol. 8, No. 2, e55499, 06.02.2013.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Chiodin M, Borve A, Berezikov E, Ladurner P, Martinez P, Hejnol A. Mesodermal Gene Expression in the Acoel Isodiametra pulchra Indicates a Low Number of Mesodermal Cell Types and the Endomesodermal Origin of the Gonads. PLoS ONE. 2013 Feb 6;8(2). e55499. https://doi.org/10.1371/journal.pone.0055499


BibTeX

@article{8997b13ccc5542529bb40bc5f183503e,
title = "Mesodermal Gene Expression in the Acoel Isodiametra pulchra Indicates a Low Number of Mesodermal Cell Types and the Endomesodermal Origin of the Gonads",
abstract = "Acoelomorphs are bilaterally symmetric small marine worms that lack a coelom and possess a digestive system with a single opening. Two alternative phylogenetic positions of this group within the animal tree are currently debated. In one view, Acoelomorpha is the sister group to all remaining Bilateria and as such, is a morphologically simple stepping stone in bilaterian evolution. In the other, the group is a lineage within the Deuterostomia, and therefore, has derived a simple morphology from a more complex ancestor. Acoels and the closely related Nemertodermatida and Xenoturbellida, which together form the Acoelomorpha, possess a very limited number of cell types. To further investigate the diversity and origin of mesodermal cell types we describe the expression pattern of 12 orthologs of bilaterian mesodermal markers including Six1/2, Twist, FoxC, GATA4/5/6, in the acoel Isodiametra pulchra. All the genes are expressed in stem cells (neoblasts), gonads, and at least subsets of the acoel musculature. Most are expressed in endomesodermal compartments of I. pulchra developing embryos similar to what has been described in cnidarians. Our molecular evidence indicates a very limited number of mesodermal cell types and suggests an endomesodermal origin of the gonads and the stem cell system. We discuss our results in light of the two prevailing phylogenetic positions of Acoelomorpha.",
keywords = "SEA-URCHIN EMBRYO, CNIDARIAN NEMATOSTELLA-VECTENSIS, LEFT-RIGHT ASYMMETRY, MUSCLE LIM PROTEIN, STEM-CELLS, TRANSCRIPTION FACTORS, FOX GENES, DEVELOPMENTAL EXPRESSION, INDEPENDENT EVOLUTION, AMPHIOXUS DEVELOPMENT",
author = "Marta Chiodin and Aina Borve and Eugene Berezikov and Peter Ladurner and Pedro Martinez and Andreas Hejnol",
year = "2013",
month = feb,
day = "6",
doi = "10.1371/journal.pone.0055499",
language = "English",
volume = "8",
journal = "PLOS-One",
issn = "1932-6203",
publisher = "PUBLIC LIBRARY SCIENCE",
number = "2",

}

RIS

TY - JOUR

T1 - Mesodermal Gene Expression in the Acoel Isodiametra pulchra Indicates a Low Number of Mesodermal Cell Types and the Endomesodermal Origin of the Gonads

AU - Chiodin, Marta

AU - Borve, Aina

AU - Berezikov, Eugene

AU - Ladurner, Peter

AU - Martinez, Pedro

AU - Hejnol, Andreas

PY - 2013/2/6

Y1 - 2013/2/6

N2 - Acoelomorphs are bilaterally symmetric small marine worms that lack a coelom and possess a digestive system with a single opening. Two alternative phylogenetic positions of this group within the animal tree are currently debated. In one view, Acoelomorpha is the sister group to all remaining Bilateria and as such, is a morphologically simple stepping stone in bilaterian evolution. In the other, the group is a lineage within the Deuterostomia, and therefore, has derived a simple morphology from a more complex ancestor. Acoels and the closely related Nemertodermatida and Xenoturbellida, which together form the Acoelomorpha, possess a very limited number of cell types. To further investigate the diversity and origin of mesodermal cell types we describe the expression pattern of 12 orthologs of bilaterian mesodermal markers including Six1/2, Twist, FoxC, GATA4/5/6, in the acoel Isodiametra pulchra. All the genes are expressed in stem cells (neoblasts), gonads, and at least subsets of the acoel musculature. Most are expressed in endomesodermal compartments of I. pulchra developing embryos similar to what has been described in cnidarians. Our molecular evidence indicates a very limited number of mesodermal cell types and suggests an endomesodermal origin of the gonads and the stem cell system. We discuss our results in light of the two prevailing phylogenetic positions of Acoelomorpha.

AB - Acoelomorphs are bilaterally symmetric small marine worms that lack a coelom and possess a digestive system with a single opening. Two alternative phylogenetic positions of this group within the animal tree are currently debated. In one view, Acoelomorpha is the sister group to all remaining Bilateria and as such, is a morphologically simple stepping stone in bilaterian evolution. In the other, the group is a lineage within the Deuterostomia, and therefore, has derived a simple morphology from a more complex ancestor. Acoels and the closely related Nemertodermatida and Xenoturbellida, which together form the Acoelomorpha, possess a very limited number of cell types. To further investigate the diversity and origin of mesodermal cell types we describe the expression pattern of 12 orthologs of bilaterian mesodermal markers including Six1/2, Twist, FoxC, GATA4/5/6, in the acoel Isodiametra pulchra. All the genes are expressed in stem cells (neoblasts), gonads, and at least subsets of the acoel musculature. Most are expressed in endomesodermal compartments of I. pulchra developing embryos similar to what has been described in cnidarians. Our molecular evidence indicates a very limited number of mesodermal cell types and suggests an endomesodermal origin of the gonads and the stem cell system. We discuss our results in light of the two prevailing phylogenetic positions of Acoelomorpha.

KW - SEA-URCHIN EMBRYO

KW - CNIDARIAN NEMATOSTELLA-VECTENSIS

KW - LEFT-RIGHT ASYMMETRY

KW - MUSCLE LIM PROTEIN

KW - STEM-CELLS

KW - TRANSCRIPTION FACTORS

KW - FOX GENES

KW - DEVELOPMENTAL EXPRESSION

KW - INDEPENDENT EVOLUTION

KW - AMPHIOXUS DEVELOPMENT

U2 - 10.1371/journal.pone.0055499

DO - 10.1371/journal.pone.0055499

M3 - Article

C2 - 23405161

VL - 8

JO - PLOS-One

JF - PLOS-One

SN - 1932-6203

IS - 2

M1 - e55499

ER -

ID: 26823311