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Merits and complexities of modeling multiple sclerosis in non-human primates: Implications for drug discovery

't Hart, B. A., Laman, J. D. & Kap, Y. S., 2018, In : Expert Opinion on Drug Discovery. 13, 5, p. 387-397 11 p.

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  • Merits and complexities of modeling multiple sclerosis in non-human primates

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DOI

Introduction: The translation of scientific discoveries made in animal models into effective treatments for patients often fails, indicating that currently used disease models in preclinical research are insufficiently predictive for clinical success. An often-used model in the preclinical research of autoimmune neurological diseases, multiple sclerosis in particular, is experimental autoimmune encephalomyelitis (EAE). Most EAE models are based on genetically susceptible inbred/SPF mouse strains used at adolescent age (10-12weeks), which lack exposure to genetic and microbial factors which shape the human immune system.

Areas covered: Herein, the authors ask whether an EAE model in adult non-human primates from an outbred conventionally-housed colony could help bridge the translational gap between rodent EAE models and MS patients. Particularly, the authors discuss a novel and translationally relevant EAE model in common marmosets (Callithrix jacchus) that shares remarkable pathological similarity with MS.

Expert opinion: The MS-like pathology in this model is caused by the interaction of effector memory T cells with B cells infected with the 1-herpesvirus (CalHV3), both present in the pathogen-educated marmoset immune repertoire. The authors postulate that depletion of only the small subset (

Original languageEnglish
Pages (from-to)387-397
Number of pages11
JournalExpert Opinion on Drug Discovery
Volume13
Issue number5
Publication statusPublished - 2018

    Keywords

  • Experimental autoimmune encephalomyelitis, animal model, marmoset, translational research, immunotherapy, B cell, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, B-CELL DEPLETION, MYELIN OLIGODENDROCYTE GLYCOPROTEIN, CENTRAL-NERVOUS-SYSTEM, CD8(+) T-CELLS, COMMON MARMOSETS, HUMAN IMMUNOLOGY, ANIMAL-MODELS, EBV INFECTION, DOUBLE-BLIND

ID: 55024916