Publication

Mendelian randomization studies of biomarkers and type 2 diabetes

Abbasi, A., 1-Dec-2015, In : Endocrine Connections. 4, 4, p. 249-260 12 p.

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APA

Abbasi, A. (2015). Mendelian randomization studies of biomarkers and type 2 diabetes. Endocrine Connections, 4(4), 249-260. https://doi.org/10.1530/EC-15-0087

Author

Abbasi, Ali. / Mendelian randomization studies of biomarkers and type 2 diabetes. In: Endocrine Connections. 2015 ; Vol. 4, No. 4. pp. 249-260.

Harvard

Abbasi, A 2015, 'Mendelian randomization studies of biomarkers and type 2 diabetes', Endocrine Connections, vol. 4, no. 4, pp. 249-260. https://doi.org/10.1530/EC-15-0087

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Mendelian randomization studies of biomarkers and type 2 diabetes. / Abbasi, Ali.

In: Endocrine Connections, Vol. 4, No. 4, 01.12.2015, p. 249-260.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Abbasi A. Mendelian randomization studies of biomarkers and type 2 diabetes. Endocrine Connections. 2015 Dec 1;4(4):249-260. https://doi.org/10.1530/EC-15-0087


BibTeX

@article{74b30a1c40e54e678ea88c1418616c60,
title = "Mendelian randomization studies of biomarkers and type 2 diabetes",
abstract = "Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomization studies that examined potential causal effects of biomarkers on T2D. To replicate the findings of identified studies, data from two large-scale, genome-wide association studies (GWAS) were used: DIAbetes Genetics Replication And Meta-analysis (DIAGRAMv3) for T2D and the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) for glycaemic traits. GWAS summary statistics were extracted for the same genetic variants (or proxy variants), which were used in the original Mendelian randomization studies. Of the 21 biomarkers (from 28 studies), ten have been reported to be causally associated with T2D in Mendelian randomization. Most biomarkers were investigated in a single cohort study or population. Of the ten biomarkers that were identified, nominally significant associations with T2D or glycaemic traits were reached for those genetic variants related to bilirubin, pro-B-type natriuretic peptide, delta-6 desaturase and dimethylglycine based on the summary data from DIAGRAMv3 or MAGIC. Several Mendelian randomization studies investigated the nature of associations of biomarkers with T2D. However, there were only a few biomarkers that may have causal effects on T2D. Further research is needed to broadly evaluate the causal effects of multiple biomarkers on T2D and glycaemic traits using data from large-scale cohorts or GWAS including many different genetic variants.",
keywords = "biomarkers, epidemiology, Mendelian randomization, genome-wide association study, type 2 diabetes, GENOME-WIDE ASSOCIATION, HORMONE-BINDING GLOBULIN, CORONARY-ARTERY-DISEASE, LIFE-STYLE INTERVENTION, INSULIN-RESISTANCE, METABOLIC SYNDROME, 25-HYDROXYVITAMIN D, GENETIC-EVIDENCE, COMMON VARIANTS, HAN CHINESE",
author = "Ali Abbasi",
year = "2015",
month = "12",
day = "1",
doi = "10.1530/EC-15-0087",
language = "English",
volume = "4",
pages = "249--260",
journal = "Endocrine Connections",
issn = "2049-3614",
publisher = "BIOSCIENTIFICA LTD",
number = "4",

}

RIS

TY - JOUR

T1 - Mendelian randomization studies of biomarkers and type 2 diabetes

AU - Abbasi, Ali

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomization studies that examined potential causal effects of biomarkers on T2D. To replicate the findings of identified studies, data from two large-scale, genome-wide association studies (GWAS) were used: DIAbetes Genetics Replication And Meta-analysis (DIAGRAMv3) for T2D and the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) for glycaemic traits. GWAS summary statistics were extracted for the same genetic variants (or proxy variants), which were used in the original Mendelian randomization studies. Of the 21 biomarkers (from 28 studies), ten have been reported to be causally associated with T2D in Mendelian randomization. Most biomarkers were investigated in a single cohort study or population. Of the ten biomarkers that were identified, nominally significant associations with T2D or glycaemic traits were reached for those genetic variants related to bilirubin, pro-B-type natriuretic peptide, delta-6 desaturase and dimethylglycine based on the summary data from DIAGRAMv3 or MAGIC. Several Mendelian randomization studies investigated the nature of associations of biomarkers with T2D. However, there were only a few biomarkers that may have causal effects on T2D. Further research is needed to broadly evaluate the causal effects of multiple biomarkers on T2D and glycaemic traits using data from large-scale cohorts or GWAS including many different genetic variants.

AB - Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomization studies that examined potential causal effects of biomarkers on T2D. To replicate the findings of identified studies, data from two large-scale, genome-wide association studies (GWAS) were used: DIAbetes Genetics Replication And Meta-analysis (DIAGRAMv3) for T2D and the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) for glycaemic traits. GWAS summary statistics were extracted for the same genetic variants (or proxy variants), which were used in the original Mendelian randomization studies. Of the 21 biomarkers (from 28 studies), ten have been reported to be causally associated with T2D in Mendelian randomization. Most biomarkers were investigated in a single cohort study or population. Of the ten biomarkers that were identified, nominally significant associations with T2D or glycaemic traits were reached for those genetic variants related to bilirubin, pro-B-type natriuretic peptide, delta-6 desaturase and dimethylglycine based on the summary data from DIAGRAMv3 or MAGIC. Several Mendelian randomization studies investigated the nature of associations of biomarkers with T2D. However, there were only a few biomarkers that may have causal effects on T2D. Further research is needed to broadly evaluate the causal effects of multiple biomarkers on T2D and glycaemic traits using data from large-scale cohorts or GWAS including many different genetic variants.

KW - biomarkers

KW - epidemiology

KW - Mendelian randomization

KW - genome-wide association study

KW - type 2 diabetes

KW - GENOME-WIDE ASSOCIATION

KW - HORMONE-BINDING GLOBULIN

KW - CORONARY-ARTERY-DISEASE

KW - LIFE-STYLE INTERVENTION

KW - INSULIN-RESISTANCE

KW - METABOLIC SYNDROME

KW - 25-HYDROXYVITAMIN D

KW - GENETIC-EVIDENCE

KW - COMMON VARIANTS

KW - HAN CHINESE

U2 - 10.1530/EC-15-0087

DO - 10.1530/EC-15-0087

M3 - Article

C2 - 26446360

VL - 4

SP - 249

EP - 260

JO - Endocrine Connections

JF - Endocrine Connections

SN - 2049-3614

IS - 4

ER -

ID: 48106785