Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

Aguilera-Gomez, A. & Rabouille, C. 15-Aug-2017 In : Developmental Biology. 428, 2, p. 310-317 8 p.

Research output: Scientific - peer-reviewArticle

Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

Original languageEnglish
Pages (from-to)310-317
Number of pages8
JournalDevelopmental Biology
Issue number2
StatePublished - 15-Aug-2017


  • Cell compartmentalization, Membrane-bound organelles, Membrane-less compartments, Liquid droplets, Liquid-liquid phase separation, Low complexity sequence, Secretory pathway, ER exit sites, gurken translation, Drosophila, Oocyte, Orb, S2 cells, COPII, Sec16, PARP16, Stress granule, mRNA, FMR1, GURKEN MESSENGER-RNA, CELL-FREE FORMATION, STRESS GRANULES, PHASE-SEPARATION, P-BODIES, COPII COAT, SECRETORY PATHWAY, ENDOPLASMIC-RETICULUM, AXIS DETERMINATION, PROCESSING BODIES

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