Publication

Melanopsin- and L-cone-induced pupil constriction is inhibited by S- and M-cones in humans

Woelders, T., Leenheers, T., Gordijn, M. C. M., Hut, R. A., Beersma, D. G. M. & Wams, E. J., 23-Jan-2018, In : Proceedings of the National Academy of Science of the United States of America. 115, 4, p. 792-797 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The human retina contains five photoreceptor types: rods; short (S)-, mid (M)-, and long (L)-wavelength-sensitive cones; and melanopsin-expressing ganglion cells. Recently, it has been shown that selective increments in M-cone activation are paradoxically perceived as brightness decrements, as opposed to L-cone increments. Here we show that similar effects are also observed in the pupillary light response, whereby M-cone or S-cone increments lead to pupil dilation whereas L-cone or melanopic illuminance increments resulted in pupil constriction. Additionally, intermittent photoreceptor activation increased pupil constriction over a 30-min interval. Modulation of L-cone or melanopic illuminance within the 0.25-4-Hz frequency range resulted in more sustained pupillary constriction than light of constant intensity. Opposite results were found for S-cone and M-cone modulations (2 Hz), mirroring the dichotomy observed in the transient responses. The transient and sustained pupillary light responses therefore suggest that S-and M-cones provide inhibitory input to the pupillary control system when selectively activated, whereas L-cones and melanopsin response fulfill an excitatory role. These findings provide insight into functional networks in the human retina and the effect of color-coding in nonvisual responses to light, and imply that nonvisual and visual brightness discrimination may share a common pathway that starts in the retina.

Original languageEnglish
Pages (from-to)792-797
Number of pages6
JournalProceedings of the National Academy of Science of the United States of America
Volume115
Issue number4
Publication statusPublished - 23-Jan-2018

    Keywords

  • human pupillary light response, silent substitution, cones, melanopsin, ipRGC, RETINAL GANGLION-CELLS, STIMULATION, LIGHT, PHOTORECEPTORS, RESPONSES, LUMINANCE, PATHWAYS, PRIMATE, COLOR
Related Publications
  1. Correction: Melanopsin- and L-cone-induced pupil constriction is inhibited by S- and M-cones in humans (vol 115, pg 792, 2018)

    Woelders, T., Leenheers, T., Gordijn, M. C. M., Hut, R. A., Beersma, D. G. M. & Wams, E. J., 27-Feb-2018, In : Proceedings of the National Academy of Science of the United States of America. 115, 9, p. E2147 1 p.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (1) »

Download statistics

No data available

ID: 54435548