Medicaments for the treatment of vasoconstriction related diseases or disorders

Henning, R. H., Euverink, G. J. W., Krenning, G. & van der Graaf, A. C., 28-Feb-2019, Patent No. WO2019038361, 23-Feb-2018, Priority date 25-Aug-2017

Research output: PatentProfessional

The present invention relates to medicaments for use in the prophylaxis or treatment of vasoconstriction related disorders or conditions. Specifically, the present invention relates to (2R) enantiomeric form of a 6-chromanol derivative for use in the prophylactic or treatment of vasoconstriction related disorders or conditions. A preferred 6-chromanol derivative is (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-l-yl)methanone; N-(benzyl)-6-hydroxy- 2,5,7, 8-tetramethylchroman-2-carboxamide; N-(phenyl)-6-hydroxy-2,5,7,8-tetramethylchroman-2- carboxamide; methyl 4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)benzoate; (6- hydroxy-2,5,7,8-tetramethylchroman-2-yl)(morpholino)methanone, and pharmaceutically acceptable salts thereof.
Original languageEnglish
Patent numberWO2019038361
Priority date25/08/2017
Filing date23/02/2018
Publication statusPublished - 28-Feb-2019

ID: 82488689