Mechanistic journeys into lipid metabolism

Oldoni, F., 2017, [Groningen]: University of Groningen. 325 p.

Research output: ThesisThesis fully internal (DIV)

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  • Title and contents

    Final publisher's version, 797 KB, PDF document

  • Chapter 1

    Final publisher's version, 709 KB, PDF document

  • Chapter 2

    Final publisher's version, 1.3 MB, PDF document

  • Chapter 3

    Final publisher's version, 2.15 MB, PDF document

  • Chapter 4

    Final publisher's version, 1.69 MB, PDF document

  • Chapter 5

    Final publisher's version, 1.21 MB, PDF document

  • Chapter 6

    Final publisher's version, 1.69 MB, PDF document

  • Chapter 7

    Final publisher's version, 1.3 MB, PDF document

  • Chapter 8

    Final publisher's version, 1.28 MB, PDF document

    Embargo ends: 16/10/2021

  • Chapter 9

    Final publisher's version, 419 KB, PDF document

  • Appendices

    Final publisher's version, 2.13 MB, PDF document

  • Complete thesis

    Final publisher's version, 13.3 MB, PDF document

    Embargo ends: 16/10/2021

  • Propositions

    Final publisher's version, 265 KB, PDF document

  • Federico Oldoni
The general scope of this thesis embraces the functional characterization of novel players or the unravelling of new roles for old players involved in dyslipidemia, impaired glucose homeostasis and atherosclerosis. Major attention is given to key molecular pathways relevant to diseased phenotypes. This was addressed by means of a wide-range of approaches including human prospective cohort studies, cellular and animal models. Three main topics are described as follows: the first part is focused on the characterization of known (LRP1) and novel (GPR146) receptors in lipid metabolism (Chapters 3 and 4). The role of established factors directly influencing HDL maturation (LCAT) or indirectly affecting HDL remodelling through TG (ANGPTL3) and their effect on cardiovascular disease is covered in Chapters 5 and 6. Finally, factors affecting triglycerides (LPL, APOA5) and carbohydrate metabolism (GALNT2) are studied in the context of metabolic syndrome in Chapters 7 and 8.
Translated title of the contributionMechanische reizen naar lipidenmetabolisme
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Award date16-Oct-2017
Place of Publication[Groningen]
Print ISBNs978-94-034-0094-5
Electronic ISBNs978-94-034-0093-8
Publication statusPublished - 2017

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