Mechanistic journeys into lipid metabolismOldoni, F., 2017, [Groningen]: University of Groningen. 325 p.
Research output: Thesis › Thesis fully internal (DIV) › Academic
The general scope of this thesis embraces the functional characterization of novel players or the unravelling of new roles for old players involved in dyslipidemia, impaired glucose homeostasis and atherosclerosis. Major attention is given to key molecular pathways relevant to diseased phenotypes. This was addressed by means of a wide-range of approaches including human prospective cohort studies, cellular and animal models. Three main topics are described as follows: the first part is focused on the characterization of known (LRP1) and novel (GPR146) receptors in lipid metabolism (Chapters 3 and 4). The role of established factors directly influencing HDL maturation (LCAT) or indirectly affecting HDL remodelling through TG (ANGPTL3) and their effect on cardiovascular disease is covered in Chapters 5 and 6. Finally, factors affecting triglycerides (LPL, APOA5) and carbohydrate metabolism (GALNT2) are studied in the context of metabolic syndrome in Chapters 7 and 8.
|Qualification||Doctor of Philosophy|
|Place of Publication||[Groningen]|
|Publication status||Published - 2017|
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