Publication

Mechanisms of vasculitis: How pauci-immune is ANCA-associated renal vasculitis?

van Paassen, P., Tervaert, J. W. C. & Heeringa, P., 2007, In : Nephron experimental nephrology. 105, 1, p. E10-E16 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

van Paassen, P., Tervaert, J. W. C., & Heeringa, P. (2007). Mechanisms of vasculitis: How pauci-immune is ANCA-associated renal vasculitis? Nephron experimental nephrology, 105(1), E10-E16. https://doi.org/10.1159/000096960

Author

van Paassen, P. ; Tervaert, J. W. Cohen ; Heeringa, P. / Mechanisms of vasculitis : How pauci-immune is ANCA-associated renal vasculitis?. In: Nephron experimental nephrology. 2007 ; Vol. 105, No. 1. pp. E10-E16.

Harvard

van Paassen, P, Tervaert, JWC & Heeringa, P 2007, 'Mechanisms of vasculitis: How pauci-immune is ANCA-associated renal vasculitis?' Nephron experimental nephrology, vol. 105, no. 1, pp. E10-E16. https://doi.org/10.1159/000096960

Standard

Mechanisms of vasculitis : How pauci-immune is ANCA-associated renal vasculitis? / van Paassen, P.; Tervaert, J. W. Cohen; Heeringa, P.

In: Nephron experimental nephrology, Vol. 105, No. 1, 2007, p. E10-E16.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

van Paassen P, Tervaert JWC, Heeringa P. Mechanisms of vasculitis: How pauci-immune is ANCA-associated renal vasculitis? Nephron experimental nephrology. 2007;105(1):E10-E16. https://doi.org/10.1159/000096960


BibTeX

@article{2c9b2a6e5cfc4099892c6306a2537281,
title = "Mechanisms of vasculitis: How pauci-immune is ANCA-associated renal vasculitis?",
abstract = "Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative lack of immunoglobulin and complement deposition within the kidney. On the other hand, evidence is accumulating that ANCA, autoantibodies against constituents of primary granules of neutrophils and the lysosomes of monocytes, play a pathogenic role in renal vasculitis. In this review we will discuss both in vitro and in vivo experimental data providing compelling evidence that ANCA are a primary pathogenic factor in renal vasculitis, mainly by augmenting leukocyte-endothelial interactions. We will also address novel data, pointing at the role of, in addition to ANCA, nonspecific proinflammatory signals. Finally, we propose a working hypothesis of the pathogenesis of ANCA-associated renal vasculitis. Copyright (c) 2007 S. Karger AG, Basel.",
keywords = "vasculitis, renal vasculitis, ANCA-associated renal vasculitis, glomerulonephritis, anti-neutrophil cytoplasmic antibody, neutrophil, ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, WEGENERS-GRANULOMATOSIS WG, NECROSIS-FACTOR-ALPHA, T-CELLS, CRESCENTIC GLOMERULONEPHRITIS, SYSTEMIC VASCULITIS, ENDOTHELIAL-CELLS, IN-VIVO, ANTIMYELOPEROXIDASE ANTIBODIES, ACTIVATE NEUTROPHILS",
author = "{van Paassen}, P. and Tervaert, {J. W. Cohen} and P. Heeringa",
year = "2007",
doi = "10.1159/000096960",
language = "English",
volume = "105",
pages = "E10--E16",
journal = "Nephron experimental nephrology",
issn = "1660-2129",
number = "1",

}

RIS

TY - JOUR

T1 - Mechanisms of vasculitis

T2 - How pauci-immune is ANCA-associated renal vasculitis?

AU - van Paassen, P.

AU - Tervaert, J. W. Cohen

AU - Heeringa, P.

PY - 2007

Y1 - 2007

N2 - Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative lack of immunoglobulin and complement deposition within the kidney. On the other hand, evidence is accumulating that ANCA, autoantibodies against constituents of primary granules of neutrophils and the lysosomes of monocytes, play a pathogenic role in renal vasculitis. In this review we will discuss both in vitro and in vivo experimental data providing compelling evidence that ANCA are a primary pathogenic factor in renal vasculitis, mainly by augmenting leukocyte-endothelial interactions. We will also address novel data, pointing at the role of, in addition to ANCA, nonspecific proinflammatory signals. Finally, we propose a working hypothesis of the pathogenesis of ANCA-associated renal vasculitis. Copyright (c) 2007 S. Karger AG, Basel.

AB - Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative lack of immunoglobulin and complement deposition within the kidney. On the other hand, evidence is accumulating that ANCA, autoantibodies against constituents of primary granules of neutrophils and the lysosomes of monocytes, play a pathogenic role in renal vasculitis. In this review we will discuss both in vitro and in vivo experimental data providing compelling evidence that ANCA are a primary pathogenic factor in renal vasculitis, mainly by augmenting leukocyte-endothelial interactions. We will also address novel data, pointing at the role of, in addition to ANCA, nonspecific proinflammatory signals. Finally, we propose a working hypothesis of the pathogenesis of ANCA-associated renal vasculitis. Copyright (c) 2007 S. Karger AG, Basel.

KW - vasculitis

KW - renal vasculitis

KW - ANCA-associated renal vasculitis

KW - glomerulonephritis

KW - anti-neutrophil cytoplasmic antibody

KW - neutrophil

KW - ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES

KW - WEGENERS-GRANULOMATOSIS WG

KW - NECROSIS-FACTOR-ALPHA

KW - T-CELLS

KW - CRESCENTIC GLOMERULONEPHRITIS

KW - SYSTEMIC VASCULITIS

KW - ENDOTHELIAL-CELLS

KW - IN-VIVO

KW - ANTIMYELOPEROXIDASE ANTIBODIES

KW - ACTIVATE NEUTROPHILS

U2 - 10.1159/000096960

DO - 10.1159/000096960

M3 - Review article

VL - 105

SP - E10-E16

JO - Nephron experimental nephrology

JF - Nephron experimental nephrology

SN - 1660-2129

IS - 1

ER -

ID: 4499357