Publication

Mechanisms of the pathogenesis of troponin T-based familial hypertrophic cardiomyopathy

Maass, AH. & Leinwand, LA., Aug-2003, In : TRENDS IN CARDIOVASCULAR MEDICINE. 13, 6, p. 232-237 6 p., PII S1050-1738(03)00100-2.

Research output: Contribution to journalReview articleAcademicpeer-review

Mutations in cardiac troponin T (cTnT) cause hypertrophic cardiomyopathy characterized by comparatively little cardiac hypertrophy, but a high incidence of sudden cardiac death. Transgenic mice modeling this disease have smaller cardiomyocytes, leading to smaller hearts. However, different mutations in cTnT have distinct phenotypes with respect to fibrosis, induction of molecular markers, and systolic function. Such models ideally allow for testing of the role of individual phenotypes in the pathways leading to cardiomyopathy, as well as identification of factors such as exercise that can affect the disease. (C) 2003, Elsevier Inc.

Original languageEnglish
Article numberPII S1050-1738(03)00100-2
Pages (from-to)232-237
Number of pages6
JournalTRENDS IN CARDIOVASCULAR MEDICINE
Volume13
Issue number6
Publication statusPublished - Aug-2003
Externally publishedYes

    Keywords

  • CHRONIC HEART-FAILURE, MEF2 TRANSCRIPTION FACTOR, CARDIAC-HYPERTROPHY, TRANSGENIC MICE, IN-VIVO, SUDDEN-DEATH, DILATED CARDIOMYOPATHY, GENE-EXPRESSION, MOUSE MODEL, CALCINEURIN

ID: 16840363