Mechanisms of naive CD4+ T cell maintenance in the elderly and its implications for Autoimmunityvan der Geest, K., Brouwer, E., Abdulahad, W. & Boots, A. M. H., 2018, Handbook of Immunosenescence: Basic Understanding and Clinical Implications. Fulop, T., Franceschi, C., Hirokawa, K. & Pawelec, G. (eds.). Springer International Publishing, p. 1-23 23 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Professional
CD4+ T cells are critical players in the immune system. CD4+ T cells coordinate both innate and adaptive immune responses. When naive CD4+ T cells become activated via their antigen-specific T cell receptor in the presence of costimulation, these cells differentiate into effector and memory T cells. Maintenance of a large and diverse naive CD4+ T cell repertoire over time is thus essential for developing immunity to a multitude of novel antigens. Despite a strong decline in thymic production of naive CD4+ T cells with aging, the circulating pool of naive CD4+ T cells is well-maintained in elderly humans. The preservation of naive CD4+ T cells in aged subjects contrasts sharply with that of naive CD8+ T cells, which decline markedly with age. In the current chapter, the mechanisms facilitating the remarkable maintenance of the naive CD4+ T cell pool with age are discussed. Important mechanisms include recognition of self-peptides by T cell receptors and stimulation by homeostatic cytokines, including interleukin-7 and interleukin-2. Furthermore, we address the implications of naive CD4+ T cell maintenance for the development of autoimmune diseases in the elderly. Lastly, two models for the development of aging-associated autoimmunity are proposed, and suggestions for further investigation are provided.
|Title of host publication||Handbook of Immunosenescence|
|Subtitle of host publication||Basic Understanding and Clinical Implications|
|Editors||Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec|
|Publisher||Springer International Publishing|
|Number of pages||23|
|Publication status||Published - 2018|