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Mechanisms of mechanosensing - mechanosensitive channels, function and re-engineering

Kocer, A., Dec-2015, In : Current Opinion in Chemical Biology. 29, p. 120-127 8 p.

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  • Current Opinion in Chemical Biology 2015 Kocer (1)

    Final publisher's version, 1.56 MB, PDF document

DOI

Sensing and responding to mechanical stimuli is an ancient behavior and ubiquitous to all forms of life. One of its players 'mechanosensitive ion channels' are involved in processes from osmosensing in bacteria to pain in humans. However, the mechanism of mechanosensing is yet to be elucidated. This review describes recent developments in the understanding of a bacterial mechanosensitive channel. Force from the lipid principle of mechanosensation, new methods to understand protein-lipid interactions, the role of water in the gating, the use of engineered mechanosensitive channels in the understanding of the gating mechanism and application of the accumulated knowledge in the field of drug delivery, drug design and sensor technologies are discussed.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume29
Publication statusPublished - Dec-2015

    Keywords

  • SENSITIVE ION-CHANNEL, MASS-SPECTROMETRY, MEMBRANE-PROTEINS, ESCHERICHIA-COLI, HYDROPHOBIC NANOPORES, OLIGOMERIC STATE, OSMOTIC-STRESS, MSCL, WATER, COMPLEXES

ID: 26476749