Mechanisms of mechanosensing - mechanosensitive channels, function and re-engineeringKocer, A., Dec-2015, In : Current Opinion in Chemical Biology. 29, p. 120-127 8 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Sensing and responding to mechanical stimuli is an ancient behavior and ubiquitous to all forms of life. One of its players 'mechanosensitive ion channels' are involved in processes from osmosensing in bacteria to pain in humans. However, the mechanism of mechanosensing is yet to be elucidated. This review describes recent developments in the understanding of a bacterial mechanosensitive channel. Force from the lipid principle of mechanosensation, new methods to understand protein-lipid interactions, the role of water in the gating, the use of engineered mechanosensitive channels in the understanding of the gating mechanism and application of the accumulated knowledge in the field of drug delivery, drug design and sensor technologies are discussed.
|Number of pages||8|
|Journal||Current Opinion in Chemical Biology|
|Publication status||Published - Dec-2015|
- SENSITIVE ION-CHANNEL, MASS-SPECTROMETRY, MEMBRANE-PROTEINS, ESCHERICHIA-COLI, HYDROPHOBIC NANOPORES, OLIGOMERIC STATE, OSMOTIC-STRESS, MSCL, WATER, COMPLEXES