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Mechanisms of enhanced thrombin generating capacity in patients with cirrhosis.

Lisman, J., Bos, S. & Intagliata, N. M., Jun-2018, In : JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 16, 6, p. 1128-1131 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

The liver is the site of synthesis of many proteins involved in hemostasis including pro- and anticoagulant proteins, pro- and antifibrinolytic proteins, and thrombopoietin. Consequently, patients with liver disease acquire complex changes within their hemostatic system[1]. Historically, these changes were thought to result in a bleeding diathesis. Although bleeding complications are common in patients with chronic liver disease, the most common bleeding complication, variceal bleeding, is a consequence of portal hypertension, rather than hemostatic failure.
Original languageEnglish
Pages (from-to)1128-1131
Number of pages4
JournalJOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume16
Issue number6
Publication statusPublished - Jun-2018

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