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Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine

Klunder, L. J., Faber, K. N., Dijkstra, G. & van IJzendoorn, S. C. D., Jul-2017, In : Cold Spring Harbor Perspectives in Biology. 9, 7, 15 p., 027888.

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  • Mechanisms of Cell Polarity–Controlled Epithelial Homeostasis and Immunity in the Intestine

    Final publisher's version, 915 KB, PDF document

DOI

Intestinal epithelial cell polarity is instrumental to maintain epithelial homeostasis and balance communications between the gut lumen and bodily tissue, thereby controlling the defense against gastrointestinal pathogens and maintenance of immune tolerance to commensal bacteria. In this review, we highlight recent advances with regard to the molecular mechanisms of cell polarity-controlled epithelial homeostasis and immunity in the human intestine.

Original languageEnglish
Article number027888
Number of pages15
JournalCold Spring Harbor Perspectives in Biology
Volume9
Issue number7
Early online date17-Feb-2017
Publication statusPublished - Jul-2017

    Keywords

  • MICROVILLUS INCLUSION DISEASE, INFLAMMATORY-BOWEL-DISEASE, BRUSH-BORDER STRUCTURE, CANINE KIDNEY-CELLS, CRYPT-VILLUS AXIS, PLASMA-MEMBRANE, TIGHT JUNCTIONS, ALPHA-5-BETA-1 INTEGRIN, TUMOR-SUPPRESSOR, APICAL MEMBRANE

ID: 40205231