Publication

Mechanisms of apical-basal axis orientation and epithelial lumen positioning

Overeem, A. W., Bryant, D. M. & van IJzendoorn, S. C. D., Aug-2015, In : Trends in Cell Biology. 25, 8, p. 476-485 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

In epithelial cells, the polarized orientation of the apical-basal axis determines the position of the apical lumen and, thereby, the collective tubular tissue architecture. From recent studies employing 3D cell cultures, animal models, and patient material, a model is emerging in which the orientation and positioning of the apical surface and lumen is controlled by the relationships between the extracellular matrix (ECM), Rho family GTPase signaling, recycling endosome dynamics, and cell division. Different epithelial cells adjust these relationships to establish their specific cell polarity orientation and lumen positioning, according to physiologic need. We provide an overview of the molecular mechanisms required to construct and orient the apical lumen.

Original languageEnglish
Pages (from-to)476-485
Number of pages10
JournalTrends in Cell Biology
Volume25
Issue number8
Publication statusPublished - Aug-2015

    Keywords

  • cell polarity, apical lumen, extracellular matrix, Rab11, recycling endosome, MICROVILLUS INCLUSION DISEASE, MITOTIC SPINDLE ORIENTATION, PLASMA-MEMBRANE DOMAINS, CELL POLARITY, HEPATOCYTE POLARIZATION, MYO5B MUTATIONS, MYOSIN VB, GLANDULAR POLARITY, RECYCLING SYSTEM, IN-VIVO

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