Mechanisms of anti-phospholipid antibody formation and actionde Groot, P. G., Feb-2011, In : Thrombosis Research. 127, p. S40-S42 3 p.
Research output: Contribution to journal › Article › Academic › peer-review
The antiphospholipid syndrome is an autoimmune disease characterised by the clinical features of recurrent thrombosis in the venous or arterial circulation and foetal losses in combination with circulating anti-phospholipid antibodies in the blood of the afflicted patients. Over the last 25 years numerous studies have established the correlation between the presence of antibodies against anionic phospholipids and thrombo-embolic manifestations but how these antibodies cause thrombosis is still unclear. Most scientists now accept the fact that only a subset of the antiphospholipid antibodies has clinical relevance. Not antibodies to anionic phospholipids but rather antibodies to beta 2-glycoprotein I are thought to be the major cause for the pathological manifestations. beta 2-Glycoprotein I is a plasma protein without a known function and persons lacking beta 2-Glycoprotein I are completely healthy. Our challenge is to understand why auto-antibodies against such a dispensable protein are so common and how antibodies directed against a protein without obvious function can induce the severe clinical manifestations observed in this syndrome. (C) 2011 Elsevier Ltd. All rights reserved.
|Number of pages||3|
|Publication status||Published - Feb-2011|
- beta 2-Glycoprotein I, Antiphospholipid antibodies, Thrombosis, Antiphospholipid syndrome, BETA(2)-GLYCOPROTEIN I, DOMAIN-I, ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODIES, AUTOANTIBODIES, ACTIVATION, THROMBOSIS, RECOGNIZE, AUTOIMMUNITY, RECEPTOR, COMPLEX