Publication

Mechanisms of anti-phospholipid antibody formation and action

de Groot, P. G., Feb-2011, In : Thrombosis Research. 127, p. S40-S42 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Philip G. de Groot

The antiphospholipid syndrome is an autoimmune disease characterised by the clinical features of recurrent thrombosis in the venous or arterial circulation and foetal losses in combination with circulating anti-phospholipid antibodies in the blood of the afflicted patients. Over the last 25 years numerous studies have established the correlation between the presence of antibodies against anionic phospholipids and thrombo-embolic manifestations but how these antibodies cause thrombosis is still unclear. Most scientists now accept the fact that only a subset of the antiphospholipid antibodies has clinical relevance. Not antibodies to anionic phospholipids but rather antibodies to beta 2-glycoprotein I are thought to be the major cause for the pathological manifestations. beta 2-Glycoprotein I is a plasma protein without a known function and persons lacking beta 2-Glycoprotein I are completely healthy. Our challenge is to understand why auto-antibodies against such a dispensable protein are so common and how antibodies directed against a protein without obvious function can induce the severe clinical manifestations observed in this syndrome. (C) 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)S40-S42
Number of pages3
JournalThrombosis Research
Volume127
Publication statusPublished - Feb-2011

    Keywords

  • beta 2-Glycoprotein I, Antiphospholipid antibodies, Thrombosis, Antiphospholipid syndrome, BETA(2)-GLYCOPROTEIN I, DOMAIN-I, ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODIES, AUTOANTIBODIES, ACTIVATION, THROMBOSIS, RECOGNIZE, AUTOIMMUNITY, RECEPTOR, COMPLEX

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