Publication

Mechanisms behind the polarized distribution of lipids in epithelial cells

van IJzendoorn, S. C. D., Agnetti, J. & Gassama-Diagne, A., 1-Feb-2020, In : Biochimica et Biophysica Acta-Biomembranes. 1862, 2, 8 p., 183145.

Research output: Contribution to journalReview articleAcademicpeer-review

Epithelial cells are polarized cells and typically display distinct plasma membrane domains: basal plasma membrane domains face the underlying tissue, lateral domains contact adjacent cells and apical domains face the exterior lumen. Each membrane domain is endowed with a specific macromolecular composition that constitutes the functional identity of that domain. Defects in apical-basal plasma membrane polarity altogether or more subtle defects in the composition of either apical or basal plasma membrane domain can give rise to severe diseases. Lipids are the main component of cellular membranes and mechanisms that control their polarized distribution in epithelial cells are emerging. In particular sphingolipids and phosphatidylinositol lipids have taken center stage in the organization of the apical and basolateral plasma membrane domain. This short review article discusses mechanisms that contribute to the polarized distribution of lipids in epithelial cells.

Original languageEnglish
Article number183145
Number of pages8
JournalBiochimica et Biophysica Acta-Biomembranes
Volume1862
Issue number2
Early online date4-Dec-2019
Publication statusPublished - 1-Feb-2020

    Keywords

  • MICROVILLUS INCLUSION DISEASE, PLASMA-MEMBRANE, TIGHT JUNCTIONS, PHOSPHOINOSITIDES, TRAFFICKING, DOMAINS, LOCALIZATION, CHOLESTEROL, DIFFUSION, PATHWAY

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