Publication

Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury

Wolthuis, E. K., Choi, G., Dessing, M. C., Bresser, P., Lutter, R., Dzoljic, M., van der Poll, T., Vroom, M. B., Hollmann, M. & Schultz, M. J., Jan-2008, In : Anesthesiology. 108, 1, p. 46-54 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Wolthuis, E. K., Choi, G., Dessing, M. C., Bresser, P., Lutter, R., Dzoljic, M., ... Schultz, M. J. (2008). Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology, 108(1), 46-54. https://doi.org/10.1097/01.anes.0000296068.80921.10

Author

Wolthuis, Esther K. ; Choi, Goda ; Dessing, Mark C. ; Bresser, Paul ; Lutter, Rene ; Dzoljic, Misa ; van der Poll, Tom ; Vroom, Margreeth B. ; Hollmann, Markus ; Schultz, Marcus J. / Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. In: Anesthesiology. 2008 ; Vol. 108, No. 1. pp. 46-54.

Harvard

Wolthuis, EK, Choi, G, Dessing, MC, Bresser, P, Lutter, R, Dzoljic, M, van der Poll, T, Vroom, MB, Hollmann, M & Schultz, MJ 2008, 'Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury', Anesthesiology, vol. 108, no. 1, pp. 46-54. https://doi.org/10.1097/01.anes.0000296068.80921.10

Standard

Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. / Wolthuis, Esther K.; Choi, Goda; Dessing, Mark C.; Bresser, Paul; Lutter, Rene; Dzoljic, Misa; van der Poll, Tom; Vroom, Margreeth B.; Hollmann, Markus; Schultz, Marcus J.

In: Anesthesiology, Vol. 108, No. 1, 01.2008, p. 46-54.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Wolthuis EK, Choi G, Dessing MC, Bresser P, Lutter R, Dzoljic M et al. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology. 2008 Jan;108(1):46-54. https://doi.org/10.1097/01.anes.0000296068.80921.10


BibTeX

@article{ff62420b624e43febe78112780141256,
title = "Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury",
abstract = "BACKGROUND: Mechanical ventilation with high tidal volumes aggravates lung injury in patients with acute lung injury or acute respiratory distress syndrome. The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury.METHODS: Patients scheduled to undergo an elective surgical procedure (lasting > or = 5 h) were randomly assigned to mechanical ventilation with either higher tidal volumes of 12 ml/kg ideal body weight and no positive end-expiratory pressure (PEEP) or lower tidal volumes of 6 ml/kg and 10 cm H2O PEEP. After induction of anesthesia and 5 h thereafter, bronchoalveolar lavage fluid and/or blood was investigated for polymorphonuclear cell influx, changes in levels of inflammatory markers, and nucleosomes.RESULTS: Mechanical ventilation with lower tidal volumes and PEEP (n = 21) attenuated the increase of pulmonary levels of interleukin (IL)-8, myeloperoxidase, and elastase as seen with higher tidal volumes and no PEEP (n = 19). Only for myeloperoxidase, a difference was found between the two ventilation strategies after 5 h of mechanical ventilation (P < 0.01). Levels of tumor necrosis factor alpha, IL-1alpha, IL-1beta, IL-6, macrophage inflammatory protein 1alpha, and macrophage inflammatory protein 1beta in the bronchoalveolar lavage fluid were not affected by mechanical ventilation. Plasma levels of IL-6 and IL-8 increased with mechanical ventilation, but there were no differences between the two ventilation groups.CONCLUSION: The use of lower tidal volumes and PEEP may limit pulmonary inflammation in mechanically ventilated patients without preexisting lung injury. The specific contribution of both lower tidal volumes and PEEP on the protective effects of the lung should be further investigated.",
keywords = "Aged, Female, Humans, Inflammation Mediators, Lung Diseases, Male, Middle Aged, Pneumonia, Positive-Pressure Respiration, Respiration, Artificial, Tidal Volume",
author = "Wolthuis, {Esther K.} and Goda Choi and Dessing, {Mark C.} and Paul Bresser and Rene Lutter and Misa Dzoljic and {van der Poll}, Tom and Vroom, {Margreeth B.} and Markus Hollmann and Schultz, {Marcus J.}",
year = "2008",
month = "1",
doi = "10.1097/01.anes.0000296068.80921.10",
language = "English",
volume = "108",
pages = "46--54",
journal = "Anesthesiology",
issn = "0003-3022",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "1",

}

RIS

TY - JOUR

T1 - Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury

AU - Wolthuis, Esther K.

AU - Choi, Goda

AU - Dessing, Mark C.

AU - Bresser, Paul

AU - Lutter, Rene

AU - Dzoljic, Misa

AU - van der Poll, Tom

AU - Vroom, Margreeth B.

AU - Hollmann, Markus

AU - Schultz, Marcus J.

PY - 2008/1

Y1 - 2008/1

N2 - BACKGROUND: Mechanical ventilation with high tidal volumes aggravates lung injury in patients with acute lung injury or acute respiratory distress syndrome. The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury.METHODS: Patients scheduled to undergo an elective surgical procedure (lasting > or = 5 h) were randomly assigned to mechanical ventilation with either higher tidal volumes of 12 ml/kg ideal body weight and no positive end-expiratory pressure (PEEP) or lower tidal volumes of 6 ml/kg and 10 cm H2O PEEP. After induction of anesthesia and 5 h thereafter, bronchoalveolar lavage fluid and/or blood was investigated for polymorphonuclear cell influx, changes in levels of inflammatory markers, and nucleosomes.RESULTS: Mechanical ventilation with lower tidal volumes and PEEP (n = 21) attenuated the increase of pulmonary levels of interleukin (IL)-8, myeloperoxidase, and elastase as seen with higher tidal volumes and no PEEP (n = 19). Only for myeloperoxidase, a difference was found between the two ventilation strategies after 5 h of mechanical ventilation (P < 0.01). Levels of tumor necrosis factor alpha, IL-1alpha, IL-1beta, IL-6, macrophage inflammatory protein 1alpha, and macrophage inflammatory protein 1beta in the bronchoalveolar lavage fluid were not affected by mechanical ventilation. Plasma levels of IL-6 and IL-8 increased with mechanical ventilation, but there were no differences between the two ventilation groups.CONCLUSION: The use of lower tidal volumes and PEEP may limit pulmonary inflammation in mechanically ventilated patients without preexisting lung injury. The specific contribution of both lower tidal volumes and PEEP on the protective effects of the lung should be further investigated.

AB - BACKGROUND: Mechanical ventilation with high tidal volumes aggravates lung injury in patients with acute lung injury or acute respiratory distress syndrome. The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury.METHODS: Patients scheduled to undergo an elective surgical procedure (lasting > or = 5 h) were randomly assigned to mechanical ventilation with either higher tidal volumes of 12 ml/kg ideal body weight and no positive end-expiratory pressure (PEEP) or lower tidal volumes of 6 ml/kg and 10 cm H2O PEEP. After induction of anesthesia and 5 h thereafter, bronchoalveolar lavage fluid and/or blood was investigated for polymorphonuclear cell influx, changes in levels of inflammatory markers, and nucleosomes.RESULTS: Mechanical ventilation with lower tidal volumes and PEEP (n = 21) attenuated the increase of pulmonary levels of interleukin (IL)-8, myeloperoxidase, and elastase as seen with higher tidal volumes and no PEEP (n = 19). Only for myeloperoxidase, a difference was found between the two ventilation strategies after 5 h of mechanical ventilation (P < 0.01). Levels of tumor necrosis factor alpha, IL-1alpha, IL-1beta, IL-6, macrophage inflammatory protein 1alpha, and macrophage inflammatory protein 1beta in the bronchoalveolar lavage fluid were not affected by mechanical ventilation. Plasma levels of IL-6 and IL-8 increased with mechanical ventilation, but there were no differences between the two ventilation groups.CONCLUSION: The use of lower tidal volumes and PEEP may limit pulmonary inflammation in mechanically ventilated patients without preexisting lung injury. The specific contribution of both lower tidal volumes and PEEP on the protective effects of the lung should be further investigated.

KW - Aged

KW - Female

KW - Humans

KW - Inflammation Mediators

KW - Lung Diseases

KW - Male

KW - Middle Aged

KW - Pneumonia

KW - Positive-Pressure Respiration

KW - Respiration, Artificial

KW - Tidal Volume

U2 - 10.1097/01.anes.0000296068.80921.10

DO - 10.1097/01.anes.0000296068.80921.10

M3 - Article

C2 - 18156881

VL - 108

SP - 46

EP - 54

JO - Anesthesiology

JF - Anesthesiology

SN - 0003-3022

IS - 1

ER -

ID: 29061587