Means and methods for site-specific labeling of proteins.Zhang, T., Bischoff, R. P. H. & Permentier, H. P., 23-Nov-2017, Patent No. WO2017200376, Priority date 17-May-2016
Research output: Patent
The invention relates to protein chemistry and protein analysis, more specifically to means and methods for the site-specific labeling of polypeptides. Provided is a method for the site-specific labelling of a polypeptide, comprising providing a polypeptide comprising at its C-terminus a reactive spirolactone moiety and reacting said spirolactone moiety with an appropriate nucleophilic labeling reagent in the presence of Cu2+ ions to provide a C-terminally labelled polypeptide. Also provided is a kit comprising reagents for performing said labeling method.
|Publication status||Published - 23-Nov-2017|