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Means and methods for mobilizing hematopoietic stem cells (HSCs).

de Haan, G., 4-Apr-2018, Patent No. EP3301175, Priority date 30-Sep-2016

Research output: PatentProfessional

The invention relates to the field of medicine, more specifically to means and methods for mobilizing hematopoietic stem cells (HSCs). Provided is a composition comprising a microRNA-125 (miR-125) nucleic acid molecule, or the complement sequence thereof, and/or an agent capable of inhibiting a target of miR-125, said target comprising in its RNA sequence the seed sequence 5'-CCUGAG-3', for use in a method for enhancing the mobilization of HSCs from the bone marrow to the peripheral blood in a subject. Also provided is a composition comprising (i) a miR-125 nucleic acid molecule, or the complement sequence thereof, and/or an agent capable of inhibiting a target of miR-125, said target comprising in its RNA sequence the seed sequence 5'-CCUGAG-3', and (ii) a further stem cell mobilization agent.
Original languageEnglish
Patent numberEP3301175
Priority date30/09/2016
Publication statusPublished - 4-Apr-2018

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