Mbth-like proteins in eukaryotic nrps-catalyzed processes

Bovenberg, R. A. L., Muller, U. M., Driessen, A. J. M., Pohl, C. & Zwahlen, R. D., 19-Oct-2017, Patent No. WO2017178624, Priority date 14-Apr-2016

Research output: PatentProfessional

The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with an MbtH-like protein. The present invention further relates to a composition comprising a eukaryotic non-ribosomal peptide synthetase that is not a hybrid and a prokaryotic MbtH and to a eukaryotic host cell comprising a non-ribosomal peptide synthetase and a polynucleotide allowing the expression of an MbtH-like protein.
Original languageEnglish
Patent numberWO2017178624
Priority date14/04/2016
Publication statusPublished - 19-Oct-2017

ID: 61203831