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Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

van Pijkeren, A., Bischoff, R. & Kwiatkowski, M., 7-Dec-2019, In : Analyst. 144, 23, p. 6812-6833 22 p.

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  • Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

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DOI

Biological organisms represent highly dynamic systems, which are continually exposed to environmental factors and always strive to restore steady-state homeostasis. Posttranslational modifications are key regulators with which biological systems respond to external stimuli. To understand how homeostasis is restored, it is important to study the kinetics of posttranslational modifications. In this review we discuss proteomic approaches using stable isotope labeled metabolic precursors to study dynamics of posttranslational modifications in cell culture.

Original languageEnglish
Pages (from-to)6812-6833
Number of pages22
JournalAnalyst
Volume144
Issue number23
Early online date29-Oct-2019
Publication statusPublished - 7-Dec-2019

    Keywords

  • ACETYL-COA SYNTHETASE, ULTRAVIOLET-LASER DESORPTION, O-GLCNAC TRANSFERASE, QUANTIFYING IN-VIVO, LYSINE ACETYLATION, HISTONE ACETYLATION, ARGININE DIMETHYLATION, PROTEOLYTIC CLEAVAGE, PROTEIN METHYLATION, HIGH-SENSITIVITY

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