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Mapping the Epigenetic Basis of Complex Traits

Cortijo, S., Wardenaar, R., Colome-Tatche, M., Gilly, A., Etcheverry, M., Labadie, K., Caillieux, E., Hospital, F., Aury, J-M., Wincker, P., Roudier, F., Jansen, R. C., Colot, V. & Johannes, F., 7-Mar-2014, In : Science. 343, 6175, p. 1145-1148 4 p.

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  • Mapping the Epigenetic Basis of Complex Traits

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DOI

  • Sandra Cortijo
  • Rene Wardenaar
  • Maria Colome-Tatche
  • Arthur Gilly
  • Mathilde Etcheverry
  • Karine Labadie
  • Erwann Caillieux
  • Frederic Hospital
  • Jean-Marc Aury
  • Patrick Wincker
  • Francois Roudier
  • Ritsert C. Jansen
  • Vincent Colot
  • Frank Johannes

Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstrate that several of these differentially methylated regions (DMRs) act as bona fide epigenetic quantitative trait loci (QTL(epi)), accounting for 60 to 90% of the heritability for two complex traits, flowering time and primary root length. These QTL(epi) are reproducible and can be subjected to artificial selection. Many of the experimentally induced DMRs are also variable in natural populations of this species and may thus provide an epigenetic basis for Darwinian evolution independently of DNA sequence changes.

Original languageEnglish
Pages (from-to)1145-1148
Number of pages4
JournalScience
Volume343
Issue number6175
Publication statusPublished - 7-Mar-2014

    Keywords

  • DNA METHYLATION, ARABIDOPSIS-THALIANA, PATTERNS, ANIMALS, PLANTS

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