Publication
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
Folkersen, L., Fauman, E., Sabater-Lleal, M., Strawbridge, R. J., Franberg, M., Sennblad, B., Baldassarre, D., Veglia, F., Humphries, S. E., Rauramaa, R., de Faire, U., Smit, A. J., Giral, P., Kurl, S., Mannarino, E., Enroth, S., Johansson, A., Enroth, S. B., Gustafsson, S., Lind, L., Lindgren, C., Morris, A. P., Giedraitis, V., Silveira, A., Franco-Cereceda, A., Tremoli, E., Gyllensten, U., Ingelsson, E., Brunak, S., Eriksson, P., Ziemek, D., Hamsten, A., Malarstig, A. & IMPROVE Study Grp, 3-Apr-2017, In : PLoS genetics. 13, 4, 21 p.Research output: Contribution to journal › Article › Academic › peer-review
Documents
- Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
Final publisher's version, 2.52 MB, PDF document
DOI
Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p
| Original language | English |
|---|---|
| Number of pages | 21 |
| Journal | PLoS genetics |
| Volume | 13 |
| Issue number | 4 |
| Publication status | Published - 3-Apr-2017 |
- GENOME-WIDE ASSOCIATION, INTIMA-MEDIA THICKNESS, GENETIC-VARIANTS, MENDELIAN RANDOMIZATION, EXPRESSION, RISK, POPULATION, CELLS, GWAS, LIFE
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Data for: Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
Folkersen, L. (Creator), Fauman, E. (Creator), Sabater-Lleal, M. (Creator), Strawbridge, R. J. (Creator), Franberg, M. (Creator), Sennblad, B. (Creator), Baldassarre, D. (Creator), Veglia, F. (Creator), Humphries, S. E. (Creator), Rauramaa, R. (Creator), de Faire, U. (Creator), Smit, A. (Creator), Giral, P. (Creator), Kurl, S. (Creator), Mannarino, E. (Creator), Enroth, S. (Creator), Johansson, A. (Creator), Enroth, S. B. (Creator), Gustafsson, S. (Creator), Lind, L. (Creator), Lindgren, C. (Creator), Morris, A. P. (Creator), Giedraitis, V. (Creator), Silveira, A. (Creator), Franco-Cereceda, A. (Creator), Tremoli, E. (Creator), Gyllensten, U. (Creator), Ingelsson, E. (Creator), Brunak, S. (Creator), Eriksson, P. (Creator), Ziemek, D. (Creator), Hamsten, A. (Creator) & Malarstig, A. (Creator), University of Groningen, 1-Mar-2017
DOI: https://doi.org/10.5281/zenodo.264128, http://www.olink-improve.com/
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