Publication

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Folkersen, L., Fauman, E., Sabater-Lleal, M., Strawbridge, R. J., Franberg, M., Sennblad, B., Baldassarre, D., Veglia, F., Humphries, S. E., Rauramaa, R., de Faire, U., Smit, A. J., Giral, P., Kurl, S., Mannarino, E., Enroth, S., Johansson, A., Enroth, S. B., Gustafsson, S., Lind, L., Lindgren, C., Morris, A. P., Giedraitis, V., Silveira, A., Franco-Cereceda, A., Tremoli, E., Gyllensten, U., Ingelsson, E., Brunak, S., Eriksson, P., Ziemek, D., Hamsten, A., Malarstig, A. & IMPROVE Study Grp, 3-Apr-2017, In : PLoS genetics. 13, 4, 21 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Lasse Folkersen
  • Eric Fauman
  • Maria Sabater-Lleal
  • Rona J. Strawbridge
  • Mattias Franberg
  • Bengt Sennblad
  • Damiano Baldassarre
  • Fabrizio Veglia
  • Steve E. Humphries
  • Rainer Rauramaa
  • Ulf de Faire
  • Andries J. Smit
  • Philippe Giral
  • Sudhir Kurl
  • Elmo Mannarino
  • Stefan Enroth
  • Asa Johansson
  • Sofia Bosdotter Enroth
  • Stefan Gustafsson
  • Lars Lind
  • Cecilia Lindgren
  • Andrew P. Morris
  • Vilmantas Giedraitis
  • Angela Silveira
  • Anders Franco-Cereceda
  • Elena Tremoli
  • Ulf Gyllensten
  • Erik Ingelsson
  • Soren Brunak
  • Per Eriksson
  • Daniel Ziemek
  • Anders Hamsten
  • Anders Malarstig
  • IMPROVE Study Grp

Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p

Original languageEnglish
Number of pages21
JournalPLoS genetics
Volume13
Issue number4
Publication statusPublished - 3-Apr-2017

    Keywords

  • GENOME-WIDE ASSOCIATION, INTIMA-MEDIA THICKNESS, GENETIC-VARIANTS, MENDELIAN RANDOMIZATION, EXPRESSION, RISK, POPULATION, CELLS, GWAS, LIFE
Related Datasets
  1. Data for: Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

    Folkersen, L. (Creator), Fauman, E. (Creator), Sabater-Lleal, M. (Creator), Strawbridge, R. J. (Creator), Franberg, M. (Creator), Sennblad, B. (Creator), Baldassarre, D. (Creator), Veglia, F. (Creator), Humphries, S. E. (Creator), Rauramaa, R. (Creator), de Faire, U. (Creator), Smit, A. (Creator), Giral, P. (Creator), Kurl, S. (Creator), Mannarino, E. (Creator), Enroth, S. (Creator), Johansson, A. (Creator), Enroth, S. B. (Creator), Gustafsson, S. (Creator), Lind, L. (Creator), Lindgren, C. (Creator), Morris, A. P. (Creator), Giedraitis, V. (Creator), Silveira, A. (Creator), Franco-Cereceda, A. (Creator), Tremoli, E. (Creator), Gyllensten, U. (Creator), Ingelsson, E. (Creator), Brunak, S. (Creator), Eriksson, P. (Creator), Ziemek, D. (Creator), Hamsten, A. (Creator) & Malarstig, A. (Creator), University of Groningen, 1-Mar-2017

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