Publication

Management around invasive procedures in mastocytosis: An update

Hermans, M. A. W., Arends, N. J. T., van Wijk, R. G., van Hagen, P. M., Kluin-Nelemans, H. C., Elberink, H. N. G. O., Pasmans, S. G. M. A. & van Daele, P. L. A., Oct-2017, In : Annals of allergy asthma & immunology. 119, 4, p. 304-309 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Copy link to clipboard

Documents

  • Management around invasive procedures in mastocytosis

    Final publisher's version, 267 KB, PDF document

DOI

Objective: Mastocytosis is a chronic hematologic disorder that is characterized by the accumulation of aberrant mast cells and typically involves the skin and/or bone marrow. Patients with mastocytosis are at increased risk of anaphylaxis. Based on theoretical assumptions, medical procedures requiring general anesthesia or radiocontrast media are deemed hazardous for patients with mastocytosis. The objective of this article is to provide a comprehensive overview of the actual risk of iatrogenic anaphylaxis and provide recommendations for daily practice.

Data Sources: Various scientific search engines were used (eg, PubMed and Medline).

Study Selections: Because of the paucity of high-level studies on this topic, all available evidence was considered, including case reports.

Results: Reliable data on the incidence of iatrogenic anaphylaxis in mastocytosis are lacking. However, although the incidence as reported in (retrospective) cohort studies is higher than in the general population, it is still lower than commonly anticipated, with an incidence of 5.4% in 1 study. Adequate premedication and avoidance of certain physical stimuli can further decrease this risk by 10-fold. The role of drugs as elicitors of anaphylaxis is perhaps overestimated, and physical stimuli are at least as important in inducing release of mast cell mediators.

Conclusion: This article provides practical recommendations for the management of invasive procedures in patients with mastocytosis based on current knowledge of this topic.

Original languageEnglish
Pages (from-to)304-309
Number of pages6
JournalAnnals of allergy asthma & immunology
Volume119
Issue number4
Publication statusPublished - Oct-2017

    Keywords

  • MAST-CELL ACTIVATION, SYSTEMIC MASTOCYTOSIS, RISK-FACTORS, SPANISH NETWORK, CONTRAST-MEDIA, CORONARY INTERVENTION, CLINICAL IMMUNOLOGY, INDUCED ANAPHYLAXIS, CYTOKINE PRODUCTION, ADVERSE-REACTIONS

ID: 50395029