Management around invasive procedures in mastocytosis: An updateHermans, M. A. W., Arends, N. J. T., van Wijk, R. G., van Hagen, P. M., Kluin-Nelemans, H. C., Elberink, H. N. G. O., Pasmans, S. G. M. A. & van Daele, P. L. A., Oct-2017, In : Annals of allergy asthma & immunology. 119, 4, p. 304-309 6 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Objective: Mastocytosis is a chronic hematologic disorder that is characterized by the accumulation of aberrant mast cells and typically involves the skin and/or bone marrow. Patients with mastocytosis are at increased risk of anaphylaxis. Based on theoretical assumptions, medical procedures requiring general anesthesia or radiocontrast media are deemed hazardous for patients with mastocytosis. The objective of this article is to provide a comprehensive overview of the actual risk of iatrogenic anaphylaxis and provide recommendations for daily practice.
Data Sources: Various scientific search engines were used (eg, PubMed and Medline).
Study Selections: Because of the paucity of high-level studies on this topic, all available evidence was considered, including case reports.
Results: Reliable data on the incidence of iatrogenic anaphylaxis in mastocytosis are lacking. However, although the incidence as reported in (retrospective) cohort studies is higher than in the general population, it is still lower than commonly anticipated, with an incidence of 5.4% in 1 study. Adequate premedication and avoidance of certain physical stimuli can further decrease this risk by 10-fold. The role of drugs as elicitors of anaphylaxis is perhaps overestimated, and physical stimuli are at least as important in inducing release of mast cell mediators.
Conclusion: This article provides practical recommendations for the management of invasive procedures in patients with mastocytosis based on current knowledge of this topic.
|Number of pages||6|
|Journal||Annals of allergy asthma & immunology|
|Publication status||Published - Oct-2017|
- MAST-CELL ACTIVATION, SYSTEMIC MASTOCYTOSIS, RISK-FACTORS, SPANISH NETWORK, CONTRAST-MEDIA, CORONARY INTERVENTION, CLINICAL IMMUNOLOGY, INDUCED ANAPHYLAXIS, CYTOKINE PRODUCTION, ADVERSE-REACTIONS