Publication

Lymphoid follicles in (very) severe COPD: beneficial or harmful?

Brusselle, G. G., Demoor, T., Bracke, K. R., Brandsma, C-A. & Timens, W., Jul-2009, In : European Respiratory Journal. 34, 1, p. 219-230 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Inflammation is a main pathogenetic factor in the development and progression of chronic obstructive pulmonary disease (COPD) Recently, it has become clear that not only the innate, but also the specific immune response plays a role. A striking finding, in particular in lungs of patients with severe COPD, often with a predominant emphysema phenotype, is the presence of B-cell follicles. As seen in other tissues, these follicles are the result of lymphoid neogenesis. The finding of oligoclonality in B-cell follicles in COPD suggests that they play a role in local antigen specific immune responses. To date, it is not known which antigens may be involved; microbial antigens, cigarette smoke-derived antigens and antigens from extracellular matrix breakdown products have been suggested. Consequently, the pathogenetic role of this follicular B-cell response is not yet clear. It might be protective against microbial colonisation and infection of the lower respiratory tract and, therefore, beneficial, or it could be of a more harmful (autoimmune) nature, directed against lung tissue components. It is necessary to determine the specific antigen(s) and to explore the exact role of the COPD related B-cell response in order to include modulation of this response and develop therapeutic options.

Original languageEnglish
Pages (from-to)219-230
Number of pages12
JournalEuropean Respiratory Journal
Volume34
Issue number1
Publication statusPublished - Jul-2009

    Keywords

  • Chronic obstructive pulmonary disease, immune response, inflammatory response, lymphocytes, review, OBSTRUCTIVE PULMONARY-DISEASE, SMOKE-INDUCED EMPHYSEMA, LUNG-VOLUME-REDUCTION, NON-HODGKINS-LYMPHOMA, CIGARETTE-SMOKE, B-CELLS, HAEMOPHILUS-INFLUENZAE, RHEUMATOID-ARTHRITIS, AIRWAY INFLAMMATION, PERIPHERAL AIRWAYS

ID: 4919549