Publication

Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury

Determann, R. M., Wolthuis, E. K., Choi, G., Bresser, P., Bernard, A., Lutter, R. & Schultz, M. J., 11-Feb-2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 2, p. L344-L350

Research output: Contribution to journalArticleAcademicpeer-review

APA

Determann, R. M., Wolthuis, E. K., Choi, G., Bresser, P., Bernard, A., Lutter, R., & Schultz, M. J. (2008). Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury. American Journal of Physiology - Lung Cellular and Molecular Physiology, 294(2), L344-L350. https://doi.org/10.1152/ajplung.00268.2007

Author

Determann, Rogier M. ; Wolthuis, Esther K. ; Choi, Goda ; Bresser, Paul ; Bernard, Alfred ; Lutter, Rene ; Schultz, Marcus J. / Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2008 ; Vol. 294, No. 2. pp. L344-L350.

Harvard

Determann, RM, Wolthuis, EK, Choi, G, Bresser, P, Bernard, A, Lutter, R & Schultz, MJ 2008, 'Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 294, no. 2, pp. L344-L350. https://doi.org/10.1152/ajplung.00268.2007

Standard

Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury. / Determann, Rogier M.; Wolthuis, Esther K.; Choi, Goda; Bresser, Paul; Bernard, Alfred; Lutter, Rene; Schultz, Marcus J.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 294, No. 2, 11.02.2008, p. L344-L350.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Determann RM, Wolthuis EK, Choi G, Bresser P, Bernard A, Lutter R et al. Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2008 Feb 11;294(2):L344-L350. https://doi.org/10.1152/ajplung.00268.2007


BibTeX

@article{071675ed4d604e1ba56dcb6b58869ad6,
title = "Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury",
abstract = "Clara cell protein levels are elevated in plasma of individuals with mild or subclinical lung injury. We studied the influence of two mechanical ventilation strategies on local and systemic levels of Clara cell protein (CC16) and compared them with levels of soluble receptor for advanced glycation end products (sRAGE) and surfactant proteins (SP)-A and -D in patients undergoing elective surgery. Saved samples from a previously reported investigation were used for the study. Forty patients planned for elective surgery were randomized to mechanical ventilation with either a conventional tidal volume (V(T)) of 12 ml/kg without positive end-expiratory pressure (PEEP) or low V(T) of 6 ml/kg and 10 cmH(2)O PEEP. Plasma and bronchoalveolar lavage fluid (BALF) was collected directly after intubation and after 5 h of mechanical ventilation. While systemic levels of SP-A and SP-D remained unchanged, systemic levels of CC16 and sRAGE increased significantly in both groups after 5 h (P < 0.001 for both). BALF levels of SP-A, SP-D, CC16, and sRAGE remained unaffected. No differences were found between the two mechanical ventilation strategies regarding any of the measured biological markers. In conclusion, systemic levels of CC16 and sRAGE rise after 5 h in patients receiving mechanical ventilation for elective surgery. Mechanical ventilation with lower tidal volumes and PEEP did not have a different effect on levels of biomarkers of lung epithelial injury compared with conventional mechanical ventilation.",
keywords = "Advanced Glycosylation End Product-Specific Receptor, Albumins, Alpha-Globulins, Biomarkers, Bronchoalveolar Lavage Fluid, Elective Surgical Procedures, Epithelium, Female, Humans, Lung Diseases, Male, Middle Aged, Perioperative Care, Pulmonary Surfactant-Associated Protein A, Pulmonary Surfactant-Associated Protein D, Receptors, Immunologic, Solubility, Tidal Volume, Uteroglobin",
author = "Determann, {Rogier M.} and Wolthuis, {Esther K.} and Goda Choi and Paul Bresser and Alfred Bernard and Rene Lutter and Schultz, {Marcus J.}",
year = "2008",
month = "2",
day = "11",
doi = "10.1152/ajplung.00268.2007",
language = "English",
volume = "294",
pages = "L344--L350",
journal = "American Journal of Physiology - Lung Cellular and Molecular Physiology",
issn = "1040-0605",
publisher = "AMER PHYSIOLOGICAL SOC",
number = "2",

}

RIS

TY - JOUR

T1 - Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury

AU - Determann, Rogier M.

AU - Wolthuis, Esther K.

AU - Choi, Goda

AU - Bresser, Paul

AU - Bernard, Alfred

AU - Lutter, Rene

AU - Schultz, Marcus J.

PY - 2008/2/11

Y1 - 2008/2/11

N2 - Clara cell protein levels are elevated in plasma of individuals with mild or subclinical lung injury. We studied the influence of two mechanical ventilation strategies on local and systemic levels of Clara cell protein (CC16) and compared them with levels of soluble receptor for advanced glycation end products (sRAGE) and surfactant proteins (SP)-A and -D in patients undergoing elective surgery. Saved samples from a previously reported investigation were used for the study. Forty patients planned for elective surgery were randomized to mechanical ventilation with either a conventional tidal volume (V(T)) of 12 ml/kg without positive end-expiratory pressure (PEEP) or low V(T) of 6 ml/kg and 10 cmH(2)O PEEP. Plasma and bronchoalveolar lavage fluid (BALF) was collected directly after intubation and after 5 h of mechanical ventilation. While systemic levels of SP-A and SP-D remained unchanged, systemic levels of CC16 and sRAGE increased significantly in both groups after 5 h (P < 0.001 for both). BALF levels of SP-A, SP-D, CC16, and sRAGE remained unaffected. No differences were found between the two mechanical ventilation strategies regarding any of the measured biological markers. In conclusion, systemic levels of CC16 and sRAGE rise after 5 h in patients receiving mechanical ventilation for elective surgery. Mechanical ventilation with lower tidal volumes and PEEP did not have a different effect on levels of biomarkers of lung epithelial injury compared with conventional mechanical ventilation.

AB - Clara cell protein levels are elevated in plasma of individuals with mild or subclinical lung injury. We studied the influence of two mechanical ventilation strategies on local and systemic levels of Clara cell protein (CC16) and compared them with levels of soluble receptor for advanced glycation end products (sRAGE) and surfactant proteins (SP)-A and -D in patients undergoing elective surgery. Saved samples from a previously reported investigation were used for the study. Forty patients planned for elective surgery were randomized to mechanical ventilation with either a conventional tidal volume (V(T)) of 12 ml/kg without positive end-expiratory pressure (PEEP) or low V(T) of 6 ml/kg and 10 cmH(2)O PEEP. Plasma and bronchoalveolar lavage fluid (BALF) was collected directly after intubation and after 5 h of mechanical ventilation. While systemic levels of SP-A and SP-D remained unchanged, systemic levels of CC16 and sRAGE increased significantly in both groups after 5 h (P < 0.001 for both). BALF levels of SP-A, SP-D, CC16, and sRAGE remained unaffected. No differences were found between the two mechanical ventilation strategies regarding any of the measured biological markers. In conclusion, systemic levels of CC16 and sRAGE rise after 5 h in patients receiving mechanical ventilation for elective surgery. Mechanical ventilation with lower tidal volumes and PEEP did not have a different effect on levels of biomarkers of lung epithelial injury compared with conventional mechanical ventilation.

KW - Advanced Glycosylation End Product-Specific Receptor

KW - Albumins

KW - Alpha-Globulins

KW - Biomarkers

KW - Bronchoalveolar Lavage Fluid

KW - Elective Surgical Procedures

KW - Epithelium

KW - Female

KW - Humans

KW - Lung Diseases

KW - Male

KW - Middle Aged

KW - Perioperative Care

KW - Pulmonary Surfactant-Associated Protein A

KW - Pulmonary Surfactant-Associated Protein D

KW - Receptors, Immunologic

KW - Solubility

KW - Tidal Volume

KW - Uteroglobin

U2 - 10.1152/ajplung.00268.2007

DO - 10.1152/ajplung.00268.2007

M3 - Article

C2 - 18083770

VL - 294

SP - L344-L350

JO - American Journal of Physiology - Lung Cellular and Molecular Physiology

JF - American Journal of Physiology - Lung Cellular and Molecular Physiology

SN - 1040-0605

IS - 2

ER -

ID: 29061528