Publication

Lung ageing and COPD: Is there a role for ageing in abnormal tissue repair?

Brandsma, C-A., de Vries, M., Costa, R., Woldhuis, R. R., Königshoff, M. & Timens, W., 31-Dec-2017, In : European Respiratory Review. 26, 146, 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Brandsma, C-A., de Vries, M., Costa, R., Woldhuis, R. R., Königshoff, M., & Timens, W. (2017). Lung ageing and COPD: Is there a role for ageing in abnormal tissue repair? European Respiratory Review, 26(146). https://doi.org/10.1183/16000617.0073-2017

Author

Brandsma, Corry-Anke ; de Vries, Maaike ; Costa, Rita ; Woldhuis, Roy R ; Königshoff, Melanie ; Timens, Wim. / Lung ageing and COPD : Is there a role for ageing in abnormal tissue repair?. In: European Respiratory Review. 2017 ; Vol. 26, No. 146.

Harvard

Brandsma, C-A, de Vries, M, Costa, R, Woldhuis, RR, Königshoff, M & Timens, W 2017, 'Lung ageing and COPD: Is there a role for ageing in abnormal tissue repair?', European Respiratory Review, vol. 26, no. 146. https://doi.org/10.1183/16000617.0073-2017

Standard

Lung ageing and COPD : Is there a role for ageing in abnormal tissue repair? / Brandsma, Corry-Anke; de Vries, Maaike; Costa, Rita; Woldhuis, Roy R; Königshoff, Melanie; Timens, Wim.

In: European Respiratory Review, Vol. 26, No. 146, 31.12.2017.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Brandsma C-A, de Vries M, Costa R, Woldhuis RR, Königshoff M, Timens W. Lung ageing and COPD: Is there a role for ageing in abnormal tissue repair? European Respiratory Review. 2017 Dec 31;26(146). https://doi.org/10.1183/16000617.0073-2017


BibTeX

@article{f71ccc5fff4747ddbec8bb395f37bb81,
title = "Lung ageing and COPD: Is there a role for ageing in abnormal tissue repair?",
abstract = "Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema. There is accumulating evidence that ageing hallmarks are prominent features of COPD. These ageing hallmarks have been described in different subsets of COPD patients, in different lung compartments and also in a variety of cell types, and thus might contribute to different COPD phenotypes. A better understanding of the main differences and similarities between normal lung ageing and the pathology of COPD may improve our understanding of the mechanisms driving COPD pathology, in particular in those patients that develop the most severe form of COPD at a relatively young age, i.e. severe early-onset COPD patients.In this review, after introducing the main concepts of lung ageing and COPD pathology, we focus on the role of (abnormal) ageing in lung remodelling and repair in COPD. We discuss the current evidence for the involvement of ageing hallmarks in these pathological features of COPD. We also highlight potential novel treatment strategies and opportunities for future research based on our current knowledge of abnormal lung ageing in COPD.",
keywords = "Journal Article",
author = "Corry-Anke Brandsma and {de Vries}, Maaike and Rita Costa and Woldhuis, {Roy R} and Melanie K{\"o}nigshoff and Wim Timens",
note = "Copyright {\circledC}ERS 2017.",
year = "2017",
month = "12",
day = "31",
doi = "10.1183/16000617.0073-2017",
language = "English",
volume = "26",
journal = "European Respiratory Review",
issn = "0905-9180",
publisher = "EUROPEAN RESPIRATORY SOC JOURNALS LTD",
number = "146",

}

RIS

TY - JOUR

T1 - Lung ageing and COPD

T2 - Is there a role for ageing in abnormal tissue repair?

AU - Brandsma, Corry-Anke

AU - de Vries, Maaike

AU - Costa, Rita

AU - Woldhuis, Roy R

AU - Königshoff, Melanie

AU - Timens, Wim

N1 - Copyright ©ERS 2017.

PY - 2017/12/31

Y1 - 2017/12/31

N2 - Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema. There is accumulating evidence that ageing hallmarks are prominent features of COPD. These ageing hallmarks have been described in different subsets of COPD patients, in different lung compartments and also in a variety of cell types, and thus might contribute to different COPD phenotypes. A better understanding of the main differences and similarities between normal lung ageing and the pathology of COPD may improve our understanding of the mechanisms driving COPD pathology, in particular in those patients that develop the most severe form of COPD at a relatively young age, i.e. severe early-onset COPD patients.In this review, after introducing the main concepts of lung ageing and COPD pathology, we focus on the role of (abnormal) ageing in lung remodelling and repair in COPD. We discuss the current evidence for the involvement of ageing hallmarks in these pathological features of COPD. We also highlight potential novel treatment strategies and opportunities for future research based on our current knowledge of abnormal lung ageing in COPD.

AB - Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema. There is accumulating evidence that ageing hallmarks are prominent features of COPD. These ageing hallmarks have been described in different subsets of COPD patients, in different lung compartments and also in a variety of cell types, and thus might contribute to different COPD phenotypes. A better understanding of the main differences and similarities between normal lung ageing and the pathology of COPD may improve our understanding of the mechanisms driving COPD pathology, in particular in those patients that develop the most severe form of COPD at a relatively young age, i.e. severe early-onset COPD patients.In this review, after introducing the main concepts of lung ageing and COPD pathology, we focus on the role of (abnormal) ageing in lung remodelling and repair in COPD. We discuss the current evidence for the involvement of ageing hallmarks in these pathological features of COPD. We also highlight potential novel treatment strategies and opportunities for future research based on our current knowledge of abnormal lung ageing in COPD.

KW - Journal Article

U2 - 10.1183/16000617.0073-2017

DO - 10.1183/16000617.0073-2017

M3 - Article

VL - 26

JO - European Respiratory Review

JF - European Respiratory Review

SN - 0905-9180

IS - 146

ER -

ID: 51399044