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Lowering of plasma phospholipid transfer protein activity by acute hyperglycaemia-induced hyperinsulinaemia in healthy men

vanTol, A., Ligtenberg, JJM., Riemens, SC., vanHaeften, TW. & Dullaart, RPF., Apr-1997, In : Scandinavian Journal of Clinical & Laboratory Investigation. 57, 2, p. 147-157 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human plasma contains two lipid transfer proteins involved in the remodelling of plasma lipoproteins: cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP). CETP mediates the transfer/exchange of cholesterylesters, triglycerides and phospholipids between high-density lipoproteins (HDL) and chylomicron (remnants), very low-density lipoproteins (VLDL) and low density lipoproteins (LDL). The physiological function of PLTP is unknown. It is able to transfer phospholipids (but not neutral lipids) between Lipoproteins and to modulate HDL particle size in vitro. The effects of acute endogenous hyperinsulinaemia on plasma CETP and PLTP activity, as well as on lipid and lipoprotein levels, were assessed in eight healthy men during a 3-h hyperglycaemic clamp. Another group of seven men received an infusion of an equal volume of saline in order to detect possible dilution effects or effects on lipoprotein changes over time (control group). Plasma cholesterol and triglyceride concentrations fell during the clamp and the decreases were significantly different from the minor changes during saline infusion in the control group (p

Original languageEnglish
Pages (from-to)147-157
Number of pages11
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume57
Issue number2
Publication statusPublished - Apr-1997

    Keywords

  • CETP, cholesterylester transfer protein, hyperinsulinaemia, insulin resistance, phospholipid transfer protein, PLTP, CHOLESTERYL ESTER TRANSFER, DENSITY-LIPOPROTEIN METABOLISM, DEPENDENT DIABETES-MELLITUS, TRANSFER EXCHANGE ACTIVITY, NONESTERIFIED FATTY-ACIDS, CORONARY HEART-DISEASE, INSULIN-RESISTANCE, CIGARETTE-SMOKING, SERUM, REDUCTION

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