Publication

Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II

Roks, A. J. M., Nijholt, J., van Buiten, A., van Gilst, W. H., de Zeeuw, D. & Henning, R. H., Dec-2004, In : Journal of Hypertension. 22, 12, p. 2355-2361 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Roks, A. J. M., Nijholt, J., van Buiten, A., van Gilst, W. H., de Zeeuw, D., & Henning, R. H. (2004). Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II. Journal of Hypertension, 22(12), 2355-2361. https://doi.org/10.1097/00004872-200412000-00018

Author

Roks, Anton J M ; Nijholt, Jeroen ; van Buiten, Azuwerus ; van Gilst, Wiek H ; de Zeeuw, Dick ; Henning, Robert H. / Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II. In: Journal of Hypertension. 2004 ; Vol. 22, No. 12. pp. 2355-2361.

Harvard

Roks, AJM, Nijholt, J, van Buiten, A, van Gilst, WH, de Zeeuw, D & Henning, RH 2004, 'Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II', Journal of Hypertension, vol. 22, no. 12, pp. 2355-2361. https://doi.org/10.1097/00004872-200412000-00018

Standard

Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II. / Roks, Anton J M; Nijholt, Jeroen; van Buiten, Azuwerus; van Gilst, Wiek H; de Zeeuw, Dick; Henning, Robert H.

In: Journal of Hypertension, Vol. 22, No. 12, 12.2004, p. 2355-2361.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Roks AJM, Nijholt J, van Buiten A, van Gilst WH, de Zeeuw D, Henning RH. Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II. Journal of Hypertension. 2004 Dec;22(12):2355-2361. https://doi.org/10.1097/00004872-200412000-00018


BibTeX

@article{963893a2af9a4199850c0bb4701a86aa,
title = "Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II",
abstract = "Objective The heptapeptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a versatile, endogenous inhibitor of the renin-angiotensin system (RAS). As the therapeutic response to exogenous RAS inhibitors, such as AT, receptor antagonists, is altered by changes in salt intake, we investigated the effect of a low, normal and high sodium diet on the antagonism of Ang II by Ang-(1-7). The role of angiotensin receptor subtypes and the endothelium was assessed.Methods Male Wistar rats received a normal sodium (0.3{\%} NaCl), high sodium (2.0{\%} NaCl) or low sodium (0.05{\%} NaCl) diet for 10 days. Vascular responses were assessed ex vivo in thoracic aortic rings in the presence of the nitric oxide (NO) inhibitor N-G-monomethyl-L-arginine (L-NMMA) to avoid aspecific vasodilator effects of Ang-(1-7).Results After a normal or high salt diet, Ang-(1-7) significantly decreased maximal Ang II-induced vascular constrictions by 40-50{\%}. After a low salt diet this noncompetitive antagonism disappeared. The AT(2) receptor antagonist PD 123319 and the Ang-(1-7) receptor antagonist A779 attenuated the effect of Ang-(1-7) found in rats fed with a normal or high sodium diet. Further, removal of endothelium and pretreatment with the prostaglandin synthesis inhibitor indomethacin (10(-5) mol/l) abolished the non-competitive antagonism by Ang-(1-7).Conclusion Ang-(1-7) elicits a specific, endothelium-dependent and non-competitive antagonism of Ang II, which involves AT(2) and Ang-(1-7) receptors but is independent of NO production. This non-competitive antagonism of Ang-(1-7) is abolished by a low sodium intake in normotensive rats, suggesting that it serves as a negative feedback towards Ang 11 in response to an altered sodium intake. (C) 2004 Lippincott Williams Wilkins.",
keywords = "Angiotensin I, Angiotensin II, Angiotensin II Type 2 Receptor Blockers, Angiotensin Receptor Antagonists, Animals, Aorta, Thoracic, Diet, Sodium-Restricted, Endothelium, Vascular, In Vitro Techniques, Male, Peptide Fragments, Rats, Rats, Wistar, Receptor, Angiotensin, Type 2, Receptors, Angiotensin, Vasoconstriction",
author = "Roks, {Anton J M} and Jeroen Nijholt and {van Buiten}, Azuwerus and {van Gilst}, {Wiek H} and {de Zeeuw}, Dick and Henning, {Robert H}",
year = "2004",
month = "12",
doi = "10.1097/00004872-200412000-00018",
language = "English",
volume = "22",
pages = "2355--2361",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "12",

}

RIS

TY - JOUR

T1 - Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II

AU - Roks, Anton J M

AU - Nijholt, Jeroen

AU - van Buiten, Azuwerus

AU - van Gilst, Wiek H

AU - de Zeeuw, Dick

AU - Henning, Robert H

PY - 2004/12

Y1 - 2004/12

N2 - Objective The heptapeptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a versatile, endogenous inhibitor of the renin-angiotensin system (RAS). As the therapeutic response to exogenous RAS inhibitors, such as AT, receptor antagonists, is altered by changes in salt intake, we investigated the effect of a low, normal and high sodium diet on the antagonism of Ang II by Ang-(1-7). The role of angiotensin receptor subtypes and the endothelium was assessed.Methods Male Wistar rats received a normal sodium (0.3% NaCl), high sodium (2.0% NaCl) or low sodium (0.05% NaCl) diet for 10 days. Vascular responses were assessed ex vivo in thoracic aortic rings in the presence of the nitric oxide (NO) inhibitor N-G-monomethyl-L-arginine (L-NMMA) to avoid aspecific vasodilator effects of Ang-(1-7).Results After a normal or high salt diet, Ang-(1-7) significantly decreased maximal Ang II-induced vascular constrictions by 40-50%. After a low salt diet this noncompetitive antagonism disappeared. The AT(2) receptor antagonist PD 123319 and the Ang-(1-7) receptor antagonist A779 attenuated the effect of Ang-(1-7) found in rats fed with a normal or high sodium diet. Further, removal of endothelium and pretreatment with the prostaglandin synthesis inhibitor indomethacin (10(-5) mol/l) abolished the non-competitive antagonism by Ang-(1-7).Conclusion Ang-(1-7) elicits a specific, endothelium-dependent and non-competitive antagonism of Ang II, which involves AT(2) and Ang-(1-7) receptors but is independent of NO production. This non-competitive antagonism of Ang-(1-7) is abolished by a low sodium intake in normotensive rats, suggesting that it serves as a negative feedback towards Ang 11 in response to an altered sodium intake. (C) 2004 Lippincott Williams Wilkins.

AB - Objective The heptapeptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a versatile, endogenous inhibitor of the renin-angiotensin system (RAS). As the therapeutic response to exogenous RAS inhibitors, such as AT, receptor antagonists, is altered by changes in salt intake, we investigated the effect of a low, normal and high sodium diet on the antagonism of Ang II by Ang-(1-7). The role of angiotensin receptor subtypes and the endothelium was assessed.Methods Male Wistar rats received a normal sodium (0.3% NaCl), high sodium (2.0% NaCl) or low sodium (0.05% NaCl) diet for 10 days. Vascular responses were assessed ex vivo in thoracic aortic rings in the presence of the nitric oxide (NO) inhibitor N-G-monomethyl-L-arginine (L-NMMA) to avoid aspecific vasodilator effects of Ang-(1-7).Results After a normal or high salt diet, Ang-(1-7) significantly decreased maximal Ang II-induced vascular constrictions by 40-50%. After a low salt diet this noncompetitive antagonism disappeared. The AT(2) receptor antagonist PD 123319 and the Ang-(1-7) receptor antagonist A779 attenuated the effect of Ang-(1-7) found in rats fed with a normal or high sodium diet. Further, removal of endothelium and pretreatment with the prostaglandin synthesis inhibitor indomethacin (10(-5) mol/l) abolished the non-competitive antagonism by Ang-(1-7).Conclusion Ang-(1-7) elicits a specific, endothelium-dependent and non-competitive antagonism of Ang II, which involves AT(2) and Ang-(1-7) receptors but is independent of NO production. This non-competitive antagonism of Ang-(1-7) is abolished by a low sodium intake in normotensive rats, suggesting that it serves as a negative feedback towards Ang 11 in response to an altered sodium intake. (C) 2004 Lippincott Williams Wilkins.

KW - Angiotensin I

KW - Angiotensin II

KW - Angiotensin II Type 2 Receptor Blockers

KW - Angiotensin Receptor Antagonists

KW - Animals

KW - Aorta, Thoracic

KW - Diet, Sodium-Restricted

KW - Endothelium, Vascular

KW - In Vitro Techniques

KW - Male

KW - Peptide Fragments

KW - Rats

KW - Rats, Wistar

KW - Receptor, Angiotensin, Type 2

KW - Receptors, Angiotensin

KW - Vasoconstriction

U2 - 10.1097/00004872-200412000-00018

DO - 10.1097/00004872-200412000-00018

M3 - Article

VL - 22

SP - 2355

EP - 2361

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 12

ER -

ID: 4285896