Publication

Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns

Zonneveld, R., Jongman, R., Juliana, A., Zijlmans, W., Plötz, F., Molema, G. & van Meurs, M., Dec-2017, In : Shock. 48, 6, p. 638-643 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Zonneveld, R., Jongman, R., Juliana, A., Zijlmans, W., Plötz, F., Molema, G., & van Meurs, M. (2017). Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns. Shock, 48(6), 638-643. https://doi.org/10.1097/SHK.0000000000000903

Author

Zonneveld, Rens ; Jongman, Rianne ; Juliana, Amadu ; Zijlmans, Wilco ; Plötz, Frans ; Molema, Grietje ; van Meurs, Matijs. / Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns. In: Shock. 2017 ; Vol. 48, No. 6. pp. 638-643.

Harvard

Zonneveld, R, Jongman, R, Juliana, A, Zijlmans, W, Plötz, F, Molema, G & van Meurs, M 2017, 'Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns', Shock, vol. 48, no. 6, pp. 638-643. https://doi.org/10.1097/SHK.0000000000000903

Standard

Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns. / Zonneveld, Rens; Jongman, Rianne; Juliana, Amadu; Zijlmans, Wilco; Plötz, Frans; Molema, Grietje; van Meurs, Matijs.

In: Shock, Vol. 48, No. 6, 12.2017, p. 638-643.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Zonneveld R, Jongman R, Juliana A, Zijlmans W, Plötz F, Molema G et al. Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns. Shock. 2017 Dec;48(6):638-643. https://doi.org/10.1097/SHK.0000000000000903


BibTeX

@article{10047e5b1c304843bd44ee48ad5aaa66,
title = "Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns",
abstract = "PURPOSE: Vascular inflammation and leakage in sepsis is mediated by Angiopoietin-1 (Ang-1) and -2 (Ang-2) and their phosphorylation of the endothelial Tie-2 receptor. Levels of Ang-2 change in adults and children during sepsis, which is associated with severity of sepsis. This study investigates levels of Ang-1 and Ang-2 in newborns to gain insight in the vascular pathophysiology of early onset sepsis (EOS) within 72 hours after birth.METHODS: A prospective cohort study was performed amongst 71 Surinamese newborns treated with antibiotics for suspected EOS and 20 control newborns. Newborns with suspected EOS were divided in two groups: blood culture negative and positive EOS. Ang-1 and Ang-2 levels were measured in serum obtained at start of antibiotic treatment and at reevaluation after 48-72 hours.RESULTS: In this cohort 8.5% of newborns had a positive blood culture. At start of antibiotic treatment Ang-1 serum levels were lower (P < 0.01), and Ang-2 and Ang-2/Ang-1 serum protein ratios higher (P < 0.01 and P < 0.01, respectively) in newborns with blood culture positive EOS than in controls. These levels were not dependent on timing of first blood draw after birth. After 48-72 hours levels of Ang-1 further decreased in blood culture positive EOS, while in the other groups no change was observed.CONCLUSIONS: Our findings support the hypothesis that a dysbalance in the Angiopoietins plays a role in the vascular pathophysiology of EOS.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.",
keywords = "Journal Article, ENDOTHELIUM, SURVIVAL, MULTIPLE-ORGAN DYSFUNCTION, NEONATAL SEPSIS, TIE2, INFLAMMATION",
author = "Rens Zonneveld and Rianne Jongman and Amadu Juliana and Wilco Zijlmans and Frans Pl{\"o}tz and Grietje Molema and {van Meurs}, Matijs",
year = "2017",
month = dec,
doi = "10.1097/SHK.0000000000000903",
language = "English",
volume = "48",
pages = "638--643",
journal = "Shock",
issn = "1073-2322",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "6",

}

RIS

TY - JOUR

T1 - Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns

AU - Zonneveld, Rens

AU - Jongman, Rianne

AU - Juliana, Amadu

AU - Zijlmans, Wilco

AU - Plötz, Frans

AU - Molema, Grietje

AU - van Meurs, Matijs

PY - 2017/12

Y1 - 2017/12

N2 - PURPOSE: Vascular inflammation and leakage in sepsis is mediated by Angiopoietin-1 (Ang-1) and -2 (Ang-2) and their phosphorylation of the endothelial Tie-2 receptor. Levels of Ang-2 change in adults and children during sepsis, which is associated with severity of sepsis. This study investigates levels of Ang-1 and Ang-2 in newborns to gain insight in the vascular pathophysiology of early onset sepsis (EOS) within 72 hours after birth.METHODS: A prospective cohort study was performed amongst 71 Surinamese newborns treated with antibiotics for suspected EOS and 20 control newborns. Newborns with suspected EOS were divided in two groups: blood culture negative and positive EOS. Ang-1 and Ang-2 levels were measured in serum obtained at start of antibiotic treatment and at reevaluation after 48-72 hours.RESULTS: In this cohort 8.5% of newborns had a positive blood culture. At start of antibiotic treatment Ang-1 serum levels were lower (P < 0.01), and Ang-2 and Ang-2/Ang-1 serum protein ratios higher (P < 0.01 and P < 0.01, respectively) in newborns with blood culture positive EOS than in controls. These levels were not dependent on timing of first blood draw after birth. After 48-72 hours levels of Ang-1 further decreased in blood culture positive EOS, while in the other groups no change was observed.CONCLUSIONS: Our findings support the hypothesis that a dysbalance in the Angiopoietins plays a role in the vascular pathophysiology of EOS.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.

AB - PURPOSE: Vascular inflammation and leakage in sepsis is mediated by Angiopoietin-1 (Ang-1) and -2 (Ang-2) and their phosphorylation of the endothelial Tie-2 receptor. Levels of Ang-2 change in adults and children during sepsis, which is associated with severity of sepsis. This study investigates levels of Ang-1 and Ang-2 in newborns to gain insight in the vascular pathophysiology of early onset sepsis (EOS) within 72 hours after birth.METHODS: A prospective cohort study was performed amongst 71 Surinamese newborns treated with antibiotics for suspected EOS and 20 control newborns. Newborns with suspected EOS were divided in two groups: blood culture negative and positive EOS. Ang-1 and Ang-2 levels were measured in serum obtained at start of antibiotic treatment and at reevaluation after 48-72 hours.RESULTS: In this cohort 8.5% of newborns had a positive blood culture. At start of antibiotic treatment Ang-1 serum levels were lower (P < 0.01), and Ang-2 and Ang-2/Ang-1 serum protein ratios higher (P < 0.01 and P < 0.01, respectively) in newborns with blood culture positive EOS than in controls. These levels were not dependent on timing of first blood draw after birth. After 48-72 hours levels of Ang-1 further decreased in blood culture positive EOS, while in the other groups no change was observed.CONCLUSIONS: Our findings support the hypothesis that a dysbalance in the Angiopoietins plays a role in the vascular pathophysiology of EOS.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.

KW - Journal Article

KW - ENDOTHELIUM

KW - SURVIVAL

KW - MULTIPLE-ORGAN DYSFUNCTION

KW - NEONATAL SEPSIS

KW - TIE2

KW - INFLAMMATION

U2 - 10.1097/SHK.0000000000000903

DO - 10.1097/SHK.0000000000000903

M3 - Article

C2 - 28538018

VL - 48

SP - 638

EP - 643

JO - Shock

JF - Shock

SN - 1073-2322

IS - 6

ER -

ID: 42510871