Publication

Low methyl-esterified pectin protects pancreatic beta-cells against diabetes-induced oxidative and inflammatory stress via galectin-3

Hu, S., Kuwabara, R., Beukema, M., Ferrari, M., de Haan, B. J., Walvoort, M. T. C., de Vos, P. & Smink, A. M., 1-Dec-2020, In : Carbohydrate Polymers. 249, 11 p., 116863.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Hu, S., Kuwabara, R., Beukema, M., Ferrari, M., de Haan, B. J., Walvoort, M. T. C., de Vos, P., & Smink, A. M. (2020). Low methyl-esterified pectin protects pancreatic beta-cells against diabetes-induced oxidative and inflammatory stress via galectin-3. Carbohydrate Polymers, 249, [116863]. https://doi.org/10.1016/j.carbpol.2020.116863

Author

Hu, Shuxian ; Kuwabara, Rei ; Beukema, Martin ; Ferrari, Michela ; de Haan, Bart J. ; Walvoort, Marthe T.C. ; de Vos, Paul ; Smink, Alexandra M. / Low methyl-esterified pectin protects pancreatic beta-cells against diabetes-induced oxidative and inflammatory stress via galectin-3. In: Carbohydrate Polymers. 2020 ; Vol. 249.

Harvard

Hu, S, Kuwabara, R, Beukema, M, Ferrari, M, de Haan, BJ, Walvoort, MTC, de Vos, P & Smink, AM 2020, 'Low methyl-esterified pectin protects pancreatic beta-cells against diabetes-induced oxidative and inflammatory stress via galectin-3', Carbohydrate Polymers, vol. 249, 116863. https://doi.org/10.1016/j.carbpol.2020.116863

Standard

Low methyl-esterified pectin protects pancreatic beta-cells against diabetes-induced oxidative and inflammatory stress via galectin-3. / Hu, Shuxian; Kuwabara, Rei; Beukema, Martin; Ferrari, Michela; de Haan, Bart J.; Walvoort, Marthe T.C.; de Vos, Paul; Smink, Alexandra M.

In: Carbohydrate Polymers, Vol. 249, 116863, 01.12.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Hu S, Kuwabara R, Beukema M, Ferrari M, de Haan BJ, Walvoort MTC et al. Low methyl-esterified pectin protects pancreatic beta-cells against diabetes-induced oxidative and inflammatory stress via galectin-3. Carbohydrate Polymers. 2020 Dec 1;249. 116863. https://doi.org/10.1016/j.carbpol.2020.116863


BibTeX

@article{98dd9121c5c045b6a478f70912367053,
title = "Low methyl-esterified pectin protects pancreatic beta-cells against diabetes-induced oxidative and inflammatory stress via galectin-3",
abstract = "Insufficient intake of dietary fibers in Western societies is considered a major contributing factor in the high incidence rates of diabetes. The dietary fiber pectin has been suggested to be beneficial for management of both Diabetes Type 1 and Type 2, but mechanisms and effects of pectin on insulin producing pancreatic beta-cells are unknown. Our study aimed to determine the effects of lemon pectins with different degree of methyl-esterification (DM) on beta-cells under oxidative (streptozotocin) and inflammatory (cytokine) stress and to elucidate the underlying rescuing mechanisms, including effects on galectin-3. We found that specific pectins had rescuing effects on toxin and cytokine induced stress on beta-cells but effects depended on the pectin concentration and DM value. Protection was more pronounced with low DM5 pectin and was enhanced with higher pectin-concentrations. Our findings show that specific pectins might prevent diabetes by making insulin producing beta-cells less susceptible for stress.",
keywords = "Dietary pectin, Streptozotocin, Inflammatory cytokine, Islet beta-cell, Type 1 Diabetes, Galectin-3, HUMAN ISLETS, MECHANISM, POLYSACCHARIDE, PURIFICATION, DISRUPTION, EXPRESSION, TRANSPORT",
author = "Shuxian Hu and Rei Kuwabara and Martin Beukema and Michela Ferrari and {de Haan}, {Bart J.} and Walvoort, {Marthe T.C.} and {de Vos}, Paul and Smink, {Alexandra M.}",
year = "2020",
month = dec,
day = "1",
doi = "10.1016/j.carbpol.2020.116863",
language = "English",
volume = "249",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "ELSEVIER SCI LTD",

}

RIS

TY - JOUR

T1 - Low methyl-esterified pectin protects pancreatic beta-cells against diabetes-induced oxidative and inflammatory stress via galectin-3

AU - Hu, Shuxian

AU - Kuwabara, Rei

AU - Beukema, Martin

AU - Ferrari, Michela

AU - de Haan, Bart J.

AU - Walvoort, Marthe T.C.

AU - de Vos, Paul

AU - Smink, Alexandra M.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Insufficient intake of dietary fibers in Western societies is considered a major contributing factor in the high incidence rates of diabetes. The dietary fiber pectin has been suggested to be beneficial for management of both Diabetes Type 1 and Type 2, but mechanisms and effects of pectin on insulin producing pancreatic beta-cells are unknown. Our study aimed to determine the effects of lemon pectins with different degree of methyl-esterification (DM) on beta-cells under oxidative (streptozotocin) and inflammatory (cytokine) stress and to elucidate the underlying rescuing mechanisms, including effects on galectin-3. We found that specific pectins had rescuing effects on toxin and cytokine induced stress on beta-cells but effects depended on the pectin concentration and DM value. Protection was more pronounced with low DM5 pectin and was enhanced with higher pectin-concentrations. Our findings show that specific pectins might prevent diabetes by making insulin producing beta-cells less susceptible for stress.

AB - Insufficient intake of dietary fibers in Western societies is considered a major contributing factor in the high incidence rates of diabetes. The dietary fiber pectin has been suggested to be beneficial for management of both Diabetes Type 1 and Type 2, but mechanisms and effects of pectin on insulin producing pancreatic beta-cells are unknown. Our study aimed to determine the effects of lemon pectins with different degree of methyl-esterification (DM) on beta-cells under oxidative (streptozotocin) and inflammatory (cytokine) stress and to elucidate the underlying rescuing mechanisms, including effects on galectin-3. We found that specific pectins had rescuing effects on toxin and cytokine induced stress on beta-cells but effects depended on the pectin concentration and DM value. Protection was more pronounced with low DM5 pectin and was enhanced with higher pectin-concentrations. Our findings show that specific pectins might prevent diabetes by making insulin producing beta-cells less susceptible for stress.

KW - Dietary pectin

KW - Streptozotocin

KW - Inflammatory cytokine

KW - Islet beta-cell

KW - Type 1 Diabetes

KW - Galectin-3

KW - HUMAN ISLETS

KW - MECHANISM

KW - POLYSACCHARIDE

KW - PURIFICATION

KW - DISRUPTION

KW - EXPRESSION

KW - TRANSPORT

UR - http://www.scopus.com/inward/record.url?scp=85089080845&partnerID=8YFLogxK

U2 - 10.1016/j.carbpol.2020.116863

DO - 10.1016/j.carbpol.2020.116863

M3 - Article

AN - SCOPUS:85089080845

VL - 249

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

M1 - 116863

ER -

ID: 132969277